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Also known as

CILP-1, HsT18872


CILP (Cartilage Intermediate Layer Protein) is a protein-coding gene that is primarily expressed in the extracellular matrix of cartilage, the connective tissue that cushions bones in joints. CILP is also expressed in other tissues, including the brain, heart, and lungs.

The CILP gene is located on chromosome 5 in humans and consists of eight exons. It encodes a protein that is involved in the development, maintenance, and repair of cartilage. Specifically, CILP is believed to play a role in the formation of the intermediate layer of cartilage, which is located between the superficial and deep layers.

Mutations or alterations in the CILP gene have been linked to various skeletal disorders, including osteoarthritis and intervertebral disc degeneration. Studies have also suggested that CILP may be involved in other conditions, such as cardiovascular disease and lung cancer, although more research is needed to confirm these associations.

Overall, CILP is an important gene involved in the regulation of cartilage development and maintenance, and its study has potential implications for understanding and treating various skeletal and other disorders.

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