Also known as
Basic transcription factor 3, BTF3a, BETA-NAC, NAC-beta
Overview
BTF3 (Basic Transcription Factor 3) is a gene that encodes a highly conserved protein involved in multiple cellular processes. The BTF3 protein functions as a general transcription factor that plays a role in RNA polymerase II-mediated transcription initiation. Additionally, BTF3 is a component of the nascent polypeptide-associated complex (NAC), which associates with newly synthesized polypeptides as they emerge from ribosomes during translation. This chaperone-like function helps protect nascent proteins from aggregation and assists in their proper folding. BTF3 is ubiquitously expressed across tissues and is essential for normal cellular function. The protein has been implicated in various cellular processes including transcription regulation, protein translation, and co-translational protein folding. While BTF3 is critical for basic cellular functions, specific genetic variants may influence transcriptional efficiency and protein synthesis capacity, potentially affecting overall cellular metabolism and stress responses.
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