Also known as
AMG, AI1E, AIH1, ALGN, AMGL, AMGX
AMELX is the gene that codes for the protein amelogenin, which is a key component of the extracellular matrix of developing teeth. Amelogenin is involved in the formation of enamel, the hard, protective outer layer of the tooth. It is expressed in the cells called ameloblasts that are responsible for forming enamel during tooth development. Amelogenin is also expressed in other tissues, including the hair and nails. Mutations in the AMELX gene can cause defects in enamel development, leading to conditions such as amelogenesis imperfecta, a disorder that affects the structure and function of teeth.
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