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Also known asADRB2R, ADRBR, B2AR, BAR, BETA2AR
ADRB2 is a gene that codes for the beta-2 adrenergic receptor, a protein located on the surface of cells in various tissues including the lungs, blood vessels, and muscles. This receptor plays a role in the regulation of cardiovascular and respiratory function by responding to signals from the hormone adrenaline and the neurotransmitter norepinephrine. Activation of the beta-2 adrenergic receptor triggers a cascade of events that result in relaxation of smooth muscle, dilation of blood vessels, and increased air flow to the lungs, among other effects. Genetic variations in the ADRB2 gene have been associated with asthma, COPD, and other respiratory disorders, as well as with cardiovascular disease and diabetes.