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The ADRA2A gene encodes the alpha-2A adrenergic receptor (ADRA2A), a member of the G protein-coupled receptor family. This receptor is activated by the neurotransmitters norepinephrine and epinephrine, and it plays a role in the regulation of cardiovascular function, sympathetic nervous system activity, and cognitive processes. The alpha-2A adrenergic receptor is primarily located in the brain and in peripheral tissues, such as the heart, blood vessels and platelets. The receptor is involved in the regulation of blood pressure, heart rate, blood flow, and platelet aggregation. Variations in the ADRA2A gene have been associated with an increased risk of hypertension, myocardial infarction, and stroke. It also has been studied as a potential therapeutic target for hypertension and cognitive disorders such as attention-deficit/hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD).

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