Also known as
SLC6A4, HTT, 5HTT, OCD1, SERT, 5-HTT, SERT1, hSERT
5-HTTLPR is a gene that codes for a protein called the serotonin transporter-linked polymorphic region. The serotonin transporter is a protein that is responsible for the reuptake of serotonin, a neurotransmitter that plays a key role in the regulation of mood, sleep, and other brain functions. The 5-HTTLPR gene is a polymorphic gene, meaning that it exists in different forms (called alleles) in the population. One form of the 5-HTTLPR gene, called the short allele, has been associated with increased risk for a number of psychiatric disorders, including depression, anxiety, and substance abuse. However, it is important to note that the relationship between 5-HTTLPR and these disorders is complex and involves multiple other genetic and environmental factors.
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