Cystic Fibrosis

Cystic Fibrosis (CF) is one of the most common life-shortening inherited diseases, affecting approximately 1 in 3,500 newborns of European ancestry. It is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time.

In people with CF, mutations in the CFTR gene cause the protein to malfunction, resulting in thick, sticky mucus that clogs the lungs and obstructs the pancreas. The mucus creates a breeding ground for bacteria, leading to chronic lung infections, inflammation, and respiratory failure. The thick mucus also prevents digestive enzymes from reaching the intestines, impairing nutrient absorption.

Symptoms vary widely but commonly include persistent coughing with thick mucus, frequent lung infections (pneumonia, bronchitis), wheezing and shortness of breath, poor growth and weight gain despite good appetite, salty-tasting skin, and male infertility. Many people with CF are diagnosed through newborn screening programs.

CF is inherited in an autosomal recessive pattern. Over 2,000 different mutations in the CFTR gene have been identified, with the F508del mutation being the most common (found in about 70% of CF patients). Recent advances in CFTR modulator therapies have significantly improved outcomes for many people with CF, targeting specific mutations to improve protein function.

NutraHacker examines the following gene related to Cystic Fibrosis:

• CFTR

For more information about your own genetic profile as related to Cystic Fibrosis, please check out our NutraHacker Carrier Status and Drug Response Report.

Or to get going without any further delay, upload raw DNA data and find out more about your carrier status today.