Brugada Syndrome

Brugada Syndrome is an inherited cardiac arrhythmia disorder characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death due to ventricular fibrillation. The condition was first described by the Brugada brothers in 1992.

The syndrome primarily affects the electrical system of the heart without causing structural abnormalities. It is responsible for approximately 4% of all sudden cardiac deaths and up to 20% of sudden deaths in people with structurally normal hearts. The condition is more common in men and in individuals of Asian descent, particularly Southeast Asian populations.

Many people with Brugada syndrome have no symptoms, and the condition may only be discovered during routine ECG testing or after a cardiac event. When symptoms occur, they typically include fainting (syncope), seizures, or sudden cardiac arrest. These events often occur during sleep, at rest, or during fever.

Brugada syndrome is most commonly caused by mutations in the SCN5A gene, which encodes a sodium channel protein critical for proper electrical conduction in the heart. The condition is inherited in an autosomal dominant pattern, meaning one copy of the altered gene is sufficient to cause the disorder.

NutraHacker examines the following gene related to Brugada Syndrome:

• SCN5A

For more information about your own genetic profile as related to Brugada Syndrome, please check out our NutraHacker WGS Critical Genetics Report.

Or to get going without any further delay, upload WGS raw DNA data and find out more about your critical genetics profile today.