Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by the progressive replacement of heart muscle cells with fatty and fibrous tissue, primarily affecting the right ventricle but often involving the left ventricle as well.

This condition is a significant cause of sudden cardiac death in young people and athletes. The structural changes in the heart muscle disrupt the normal electrical pathways, leading to potentially life-threatening arrhythmias (irregular heartbeats), particularly during physical exertion.

Symptoms may include palpitations, fainting (syncope), shortness of breath, and in some cases, sudden cardiac arrest. However, some individuals may be asymptomatic for years before the disease manifests. The condition typically becomes apparent during adolescence or early adulthood.

ARVC is most commonly inherited in an autosomal dominant pattern, meaning a single copy of the altered gene is sufficient to cause the condition. The disease is primarily caused by mutations in genes encoding desmosomal proteins, which are essential for cell-to-cell adhesion in heart muscle.

NutraHacker examines the following genes related to Arrhythmogenic Right Ventricular Cardiomyopathy:

• DSC2
• DSG2
• DSP
• PKP2
• TMEM43
• DES

For more information about your own genetic profile as related to Arrhythmogenic Right Ventricular Cardiomyopathy, please check out our NutraHacker WGS Critical Genetics Report.

Or to get going without any further delay, upload WGS raw DNA data and find out more about your critical genetics profile today.