Royal Jelly - NutraPedia

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Royal Jelly Overview

1) Conditions Studied for Royal Jelly

Royal jelly has been studied for a variety of conditions, including but not limited to:

  • Menopausal symptoms
  • High cholesterol
  • Diabetes
  • Infertility issues
  • Wound healing and skin disorders
  • Immune system enhancement

2) Efficacy in Treating Conditions

The effectiveness of royal jelly in treating these conditions is still under scientific investigation, with mixed results:

  • Some studies suggest benefits in menopausal symptoms and wound healing.
  • There is limited evidence on its positive effects on cholesterol and diabetes.
  • Research on fertility and immune system improvement is inconclusive.

More rigorous and extensive clinical trials are needed to substantiate these claims.

3) Health Benefits of Royal Jelly

Royal jelly may offer several health benefits, such as:

  • Antioxidant properties
  • Anti-inflammatory effects
  • Potential to improve cognitive function
  • May support skin health

However, it's important to note that the evidence for these benefits varies in quality and is not universally accepted.

4) Downsides of Royal Jelly

While many people can safely consume royal jelly, there are potential downsides:

  • Allergic reactions, particularly in individuals who are allergic to bees or bee products
  • Possible interactions with certain medications
  • Quality and potency can vary between products

It is recommended to consult with a healthcare provider before beginning any new supplement regimen, including royal jelly.

5) Royal Jelly and Genetic Variations

Research on the relationship between royal jelly and specific genetic variations is limited. However, here are a few considerations:

  • Individuals with certain genetic predispositions to allergies may have an increased risk of adverse reactions to royal jelly.
  • There is ongoing research into how genetic variations may affect the metabolism and effectiveness of various supplements, including royal jelly.

Until more definitive research is available, it is difficult to make concrete statements about the benefits or harms of royal jelly for specific genetic variations.

Royal Jelly Research Summary

Development of UPLC Method for RJ Freshness: A study developed a rapid ultraperformance liquid chromatography (UPLC) method to assess the freshness and quality of royal jelly (RJ) by measuring ATP and its breakdown products. The recovery rates were between 86.0% and 102.3% with high precision and the method was successfully applied to RJ samples.

10-Hydroxy-trans-2-decenoic Acid in RJ: Research found that 10-Hydroxy-trans-2-decenoic acid (10H2DA), a major RJ component, inhibits the production of nitric oxide and tumor necrosis factor-alpha, potentially modulating immune responses.

Choline Esters in RJ: A study focused on confirming the presence of acetylcholine, a known neurotransmitter, in royal jelly, suggesting significant biological functions for RJ components.

Protective Effects of RJ on Chemotherapy Damage: RJ showed protective effects against oxidative stress and apoptosis in the liver and kidneys of rats caused by the chemotherapy drug cisplatin.

RJ in Preventing and Treating Periodontal Diseases: RJ was found to have bone-inducing (osteoinductive) and anti-inflammatory effects, beneficial for managing periodontal diseases.

Anti-Aging Effects of RJ on Skin: Research indicated that RJ may protect against skin aging by promoting collagen production, particularly in rats with estrogen deficiency.

Queen Differentiation Induced by Royalactin: Royalactin, a protein in RJ, was shown to induce larval development into queens in honeybees and had similar effects on fruit flies, suggesting its action via the Egfr signaling pathway.

RJ and Traditional Medicines for Mibyou: RJ's weak estrogenic activity was studied, revealing its ability to bind to human estrogen receptors and promote cell proliferation, which may offer pharmacological functions.

RJ Protects against Paracetamol-Induced Liver Damage: A study concluded that royal jelly could significantly protect the liver from damage induced by paracetamol.

Negative Impacts of RJ on Pubertal Male Rats: High doses of RJ adversely affected the reproductive system of young male rats, with potential partial recovery after discontinuation.

Insulin-like and Immunological Activities in RJ: Research investigated RJ's hypoglycemic effects and immunological properties, contributing to its use in alternative medicine.

Immunomodulatory Effects of RJ Fatty Acids: Fatty acids in RJ, such as 10-HDA and 3,10-DDA, were found to have immunomodulatory effects, influencing T-cell and dendritic cell cultures.

RJ and Bee Pollen on Osteoporosis: RJ and bee pollen decreased bone loss in an oophorectomized rat model, suggesting implications for treating osteoporosis.

AMP N1-oxide in RJ and Nerve Growth: AMP N1-oxide, identified in RJ, was significantly more potent than AMP in inducing nerve growth-promoting activity in rat pheochromocytoma PC12 cells.

Allergic Reactions to RJ: An individual with asthma experienced a severe reaction after consuming RJ, emphasizing potential risks for those with respiratory conditions.

Estrogen-like Effects of RJ Fatty Acids: RJ-derived fatty acids impacted estrogen receptor functions, suggesting a novel mechanism of estrogenic activity.

IgE-mediated Hypersensitivity to RJ: A study confirmed that asthma and anaphylaxis symptoms after RJ ingestion were true IgE-mediated hypersensitivity reactions.

Long-term RJ Consumption Benefits: A six-month study showed that RJ consumption led to better red blood cell production, glucose tolerance, and mental health in humans.

RJ on Autoimmune Responses in Graves' Disease: RJ acted as an immunomodulatory agent in Graves' disease treatment, potentially offering an alternative to conventional drugs.

RJ Effect on Lipoprotein Metabolism: RJ supplementation significantly reduced serum total cholesterol and LDL, suggesting improvements in cholesterol profiles.

Mimicking Estrogen with RJ: RJ weakly bound to human estrogen receptors, influencing gene transcription and potentially relieving menopausal symptoms.

Melbrosia for Menopausal Symptoms: Melbrosia, containing bee products, was found to reduce menopausal symptoms and improve cardiovascular markers in postmenopausal women.

Lifespan-Extending Effects of RJ: RJ and protease-treated RJ increased the lifespan of C. elegans by activating longevity-associated pathways, suggesting its potential in promoting longevity.


  1. Fast determination of adenosine 5'-triphosphate (ATP) and its catabolites in royal jelly using ultraperformance liquid chromatography
  2. Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction
  3. [Identification of choline esters in biological material, especially acetylcholine in royal jelly of bee]
  4. Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin
  5. Osteoinductive and anti-inflammatory effect of royal jelly on periodontal ligament cells
  6. Royal jelly increases collagen production in rat skin after ovariectomy
  7. Royalactin induces queen differentiation in honeybees
  8. [Novel approach to curatives of Mibyou (presymptomatic diseases)]
  9. The effects of royal jelly on liver damage induced by paracetamol in mice
  10. Influence of royal jelly on the reproductive function of puberty male rats
  11. Insulin-like hypoglycemic and immunological activities in honeybee royal jelly
  12. Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro
  13. Royal jelly and bee pollen decrease bone loss due to osteoporosis in an oophorectomized rat model
  14. Identification of AMP N1-oxide in royal jelly as a component neurotrophic toward cultured rat pheochromocytoma PC12 cells
  15. Fatal royal jelly-induced asthma
  16. Fatty acids derived from royal jelly are modulators of estrogen receptor functions
  17. Asthma and anaphylaxis induced by royal jelly
  18. Effect of royal jelly ingestion for six months on healthy volunteers
  19. The effects of royal jelly on autoimmunity in Graves' disease
  20. Royal jelly supplementation improves lipoprotein metabolism in humans
  21. Royal jelly has estrogenic effects in vitro and in vivo
  22. Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trial
  23. [Biochemical studies on vasodilative factor in royal jelly (author's transl)]
  24. Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression
  25. Serum and liver tissue bio-element levels, and antioxidant enzyme activities in carbon tetrachloride-induced hepatotoxicity: protective effects of royal jelly
  26. Royal jelly counteracts bucks' "summer infertility"
  27. Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats
  28. Effect of royal jelly on serum lipids in experimental animals and humans with atherosclerosis
  29. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series
  30. Bronchospasm induced by royal jelly
  31. Testosterone, epitestosterone and androstenedione in the pollen of Scotch pine P. silvestris L
  32. Royal jelly increases high density lipoprotein levels but in older patients only
  33. Characterization of major allergens of royal jelly Apis mellifera
  34. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans
  35. Role of lycopene in recovery of radiation induced injury to mammalian cellular organelles
  36. Asthma following royal jelly
  37. Characterization of royal jelly proteins in both Africanized and European honeybees (Apis mellifera) by two-dimensional gel electrophoresis
  38. Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines

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