Methylsulfonylmethane (MSM) Overview

1) Conditions Studied for MSM

MSM has been studied for various conditions, including:

• Osteoarthritis and joint pain
• Inflammatory disorders
• Muscle pain and spasms
• Exercise-induced muscle damage
• Allergic rhinitis
• Skin conditions such as rosacea

2) Efficacy in Treating Conditions

Research on MSM's effectiveness has shown mixed results:

• Some studies suggest that MSM may help reduce joint pain and inflammation, improving quality of life for individuals with osteoarthritis.
• It may have anti-inflammatory properties that could benefit those with allergic rhinitis.
• There is limited evidence that MSM can improve skin health and appearance.
• More research is needed to conclusively determine its efficacy for various conditions.

3) Health Benefits of MSM

Reported health benefits of MSM include:

• Reduction in joint pain and stiffness
• Decreased inflammation
• Improved skin health and complexion
• Support for muscle recovery post-exercise
• Potential anti-allergic properties

4) Downsides of MSM

While MSM is generally considered safe, there may be downsides:

• Some individuals may experience gastrointestinal side effects, such as nausea, diarrhea, and bloating.
• Headaches and allergic reactions have been reported in rare cases.
• Long-term safety data is limited, and its interaction with other medications is not fully understood.

5) MSM and Genetic Variations

There is limited research on the interaction between MSM and specific genetic variations:

• Currently, no conclusive evidence suggests MSM is either particularly beneficial or harmful for specific genetic variations.
• Individual responses to MSM supplementation may vary, and genetic factors could play a role in this variability.
• Further research is needed to understand the potential genetic interactions with MSM.

MSM (Methylsulfonylmethane) Research Summaries

MSM Monograph Overview

A monograph for MSM would detail its chemical properties, biological effects, safety, and therapeutic uses. It is commonly used to treat pain, inflammation, and allergies. Dosages, side effects, and interactions are also discussed.

MSM in Treating Osteoarthritis

Research on MSM's effectiveness in treating osteoarthritis is inconclusive. While some studies show pain improvement, methodological issues such as proper dosage and treatment duration present challenges.

MSM Pharmacokinetics in Rats

MSM is rapidly absorbed, distributed across tissues, and excreted from the rat's body. Peak blood levels are reached within hours and the compound is fully cleared within 120 hours.

Quality Control of Supplements

Reflectance Near-Infrared (RNIR) spectroscopy, alongside chemometric techniques, can accurately measure levels of MSM in tablets, making it an effective quality control method for pharmaceuticals.

Consumer Choices in Natural Health Products

When choosing natural health products for osteoarthritis, consumers often value advice from health care providers over scientific evidence, indicating a contextual approach in decision-making.

MSM and DMSO as Solvents

Computational studies show that MSM and DMSO have high polarity and boiling points due to strong electrostatic sites on their sulfur atoms, explaining their solvent capabilities.

MSM in Plasma and Urine

Studies show that MSM can be detected in human plasma and urine, and its levels can be influenced by dietary intake, metabolism, and certain health conditions.

MSM and Osteoarthritis Pain Relief

MSM supplementation showed some improvements in pain and physical function in patients with knee osteoarthritis, but further research is needed to confirm long-term benefits and safety.

MSM and Cataract Management

Combining MSM with EDTA may offer a new approach for cataract management by enhancing antioxidant capacity and reducing lens cloudiness.

MSM Toxicity Studies

Toxicity studies in rats indicate that MSM is safe even at high doses, with no adverse effects or pathological changes observed.

MSM in Pregnancy

MSM administered to pregnant rats showed no signs of maternal or developmental toxicity, suggesting it is not harmful during pregnancy at tested doses.

References:

1. Methylsulfonylmethane (MSM). Monograph
2. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis
3. Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats
4. Reflectance near-infrared spectroscopic method with Chemometric techniques for simultaneous determination of Chondroitin, glucosamine, and methyl sulfonyl methane
5. Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach
6. Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
7. Dimethyl sulfone: isolation from cows' milk
8. Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages
9. Fate and metabolism of dimethyl sulfoxide in agricultural crops
10. Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants
11. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR
12. Elemental sulfur identified in urine of cheetah, Acinonyx jubatus
13. Identification of volatiles from the secretions and excretions of African wild dogs (Lycaon pictus)
14. Metabolism of dimethyl sulfide, dimethyl sulfoxide, and dimethyl sulfone in the rabbit
15. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins
16. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation
17. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
18. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy
19. Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid
20. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
21. Dimethylsulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: a possible mechanism of analgesia
22. The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
23. Right ventricular performance after monocrotaline-induced pulmonary hypertension
24. Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats
25. Sulfur in human nutrition and applications in medicine
26. Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats
27. Association between use of specialty dietary supplements and C-reactive protein concentrations
28. Dimethyl sulfoxide modulation of diabetes onset in NOD mice
29. Dimethyl sulfoxide (DMSO): a review
30. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide
31. Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
32. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages
33. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model
34. Calcium, sulfur, and zinc distribution in normal and arthritic articular equine cartilage: a synchrotron radiation-induced X-ray emission (SRIXE) study
35. Difficulties with assessing the benefit of glucosamine sulphate as a treatment for osteoarthritis
36. Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulfur amino acids
37. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis
38. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: more data needed on pollen counts and questionnaire
39. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: additional data on pollen counts and symptom questionnaire
40. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study
41. Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity
42. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men
43. Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study
44. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
45. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis
46. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
47. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial
48. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis
49. MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs
50. Cytotoxicity of methylsulfonylmethane on gastrointestinal (AGS, HepG2, and KEYSE-30) cancer cell lines
51. Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways
52. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line
53. Expression of the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs) in human gastric cancer cells
54. PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells
55. The signals and pathways activating cellular senescence
56. Senescence induction; a possible cancer therapy
57. Tumor cell senescence in cancer treatment
58. The effect of methylsulfonylmethane on the experimental colitis in the rat
59. Effect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled study
60. Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial
61. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation
62. Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel
63. Physicochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: kinetic and thermodynamic determinants of dimethyl sulfoxide mediated mass transfer of alkanols
64. TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE. 1
65. The effect of dimethyl sulfoxide on the epidermal water barrier
66. Ultrastructural changes in the horny layer following local application of dimethyl sulfoxide
67. Ultrastructural studies of barrier restoration in epidermis of hairless mice following dimethyl sulfoxide application
68. Investigation of iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity
69. Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy
70. Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract
71. Toxicity of methylsulfonylmethane in rats
72. Oral developmental toxicity study of methylsulfonylmethane in rats

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