Mondo Grass - NutraPedia

Back to Table of Contents

Mondo Grass Overview

1) Conditions Studied

As of my knowledge cutoff date, Mondo Grass (Ophiopogon japonicus) has been studied in traditional medicine for various conditions. However, there is limited scientific research available to validate its use for specific health conditions.

2) Efficacy in Treating Conditions

Due to the scarcity of rigorous scientific studies, it is difficult to conclusively determine the efficacy of Mondo Grass in treating health conditions. More research is needed to verify its therapeutic effects.

3) Health Benefits

While traditional uses suggest several health benefits, such as improving respiratory and digestive health, these claims lack substantial scientific evidence. It is important to consult healthcare professionals before using Mondo Grass for health purposes.

4) Potential Downsides

Mondo Grass is generally considered safe when used as an ornamental plant. If used medicinally, potential downsides could include allergic reactions or interactions with other medications. It is always advised to use caution and seek professional advice before using it for medicinal purposes.

5) Impact on Genetic Variations

There is no widely available research on the effects of Mondo Grass on specific genetic variations. Individual responses to herbal treatments can vary, so it is advisable to consider personalized medical advice.

Mondo Grass (Ophiopogon japonicus) Research Overview

Phytochemical Studies and Compound Discoveries

New steroidal saponin compounds were identified from Mondo Grass, including two furostanol saponins with disaccharide chains. Another compound demonstrated neurite growth in neural cell models.

Anti-Diabetic Effects of MDG-1

Research on MDG-1, a water-soluble β-d-fructan from Mondo Grass, showed it significantly reduced blood sugar and insulin resistance in diabetic mice, suggesting it as a promising anti-diabetic agent.

Cardiovascular System Impact

Several new compounds were isolated from Mondo Grass, with some showing potential to enhance human myocardial microvascular endothelial cell tube formation, indicating cardiovascular system benefits.

Anti-Aging and Lifespan Extension

A steroidal saponin from Mondo Grass was found to extend the lifespan of yeast by combating oxidative stress and enhancing antioxidant gene expression, highlighting its anti-aging properties.

Immunomodulatory Properties

Sulfated polysaccharides derived from Mondo Grass showed improved immune-enhancing effects on chicken lymphocyte proliferation and serum antibody levels compared to their non-sulfated counterparts.

Neuroprotective and Anti-Inflammatory Effects

Ruscogenin, a compound in Mondo Grass, was found to protect against cerebral ischemia-induced brain damage in mice by inhibiting inflammatory NF-κB signaling pathway activation.

Conclusion

The diverse research on Ophiopogon japonicus has uncovered multiple compounds with promising pharmacological potentials, including anti-diabetic, cardiovascular, anti-aging, immunomodulatory, and neuroprotective effects.

References:


  1. Two novel furostanol saponins from the tubers of Ophiopogon japonicus
  2. MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model
  3. New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
  4. Chemical constituents from the fibrous root of Ophiopogon japonicus, and their effect on tube formation in human myocardial microvascular endothelial cells
  5. A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1
  6. Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus
  7. Comparative studies on the constituents of ophiopogonis tuber and its congeners. VIII. Studies on the glycosides of the subterranean part of Ophiopogon japonicus Ker-Gawler cv. Nanus
  8. Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler
  9. Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat
  10. Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats
  11. [Isolation, purification and structural analysis of a polysaccharide MDG-1 from Ophiopogon japonicus]
  12. Structure and antioxidant activity of polysaccharide POJ-U1a extracted by ultrasound from Ophiopogon japonicus
  13. Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide
  14. Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl
  15. Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke


Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!