Korean Black Raspberry: Health Aspects

1) Conditions Studied

Korean Black Raspberry, scientifically known as Rubus coreanus, has been studied for a variety of health conditions. Research has explored its potential effects on cardiovascular diseases, diabetes, cancer, inflammation, as well as its antioxidative properties.

2) Effectiveness in Treating Conditions

While some studies suggest that Korean Black Raspberry may have beneficial effects due to its antioxidative and anti-inflammatory properties, more research is needed to conclusively determine its effectiveness in treating specific conditions. Current evidence is promising but not definitive.

3) Health Benefits

• Antioxidant Support: High in antioxidants, which help neutralize harmful free radicals in the body.
• Anti-inflammatory Properties: Contains compounds that may reduce inflammation.
• Cardiovascular Health: May improve heart health by affecting lipid profiles and blood pressure.
• Anti-cancer Potential: Some studies have indicated it could have anti-cancer properties, though more research is needed.
• Blood Sugar Regulation: May aid in controlling blood sugar levels, beneficial for those with diabetes.

4) Downsides

Generally, Korean Black Raspberry is considered safe when consumed in food amounts. However, there is limited information on the safety of taking high doses or using supplements. Potential downsides could include allergic reactions or interactions with certain medications. Always consult with a healthcare provider before starting any new supplement regimen.

5) Genetic Variations Impact

There is currently limited research on the interaction between Korean Black Raspberry and specific genetic variations. Some individuals with certain genetic predispositions may experience more pronounced benefits or side effects, but this area requires further study to draw any solid conclusions.

Korean Black Raspberry (Rubus coreanus) Research Summary

Immune Enhancement in Shrimp

An ethanolic extract from Rubus coreanus was found to boost immune gene expression and antioxidant enzymes in white leg shrimp, leading to enhanced disease resistance.

Antioxidant Properties of R. coreanus Seed Extracts

Extracts from the seeds of Bokbunja, a byproduct of wine production, showed higher antioxidant activities compared to extracts from fresh seeds, with potential applications in food and other industries.

Composition of R. coreanus Seed Oils

Seed oils from fresh and wine processing waste of Bokbunja fruits were analyzed, revealing similar fatty acid profiles but higher free fatty acid content in wine waste oil.

Extraction of Anthocyanins from Bokbunja Marc

Optimal conditions for anthocyanin extraction from Bokbunja marc were identified, noting significant changes in carbohydrates during yeast fermentation.

R. coreanus Extract and Erectile Function

Unripe R. coreanus extract was shown to relax smooth muscle cells in rabbit corpus cavernosum and improve the efficacy of sildenafil, suggesting potential for ED treatment.

Neuroprotective Properties of R. coreanus Anthocyanins

Anthocyanins extracted from ripe R. coreanus fruits displayed antioxidant and neuroprotective properties, hinting at potential health benefits for the brain.

Antiulcer Effects of R. coreanus Anthocyanins

Anthocyanins from Korean black raspberry showed protective effects against gastric ulcers in rats by modulating antioxidant defenses and inflammation.

Microwave-Assisted Extraction of R. coreanus

Optimization of microwave-assisted extraction of raspberry polyphenols and antioxidants was achieved, highlighting their use as natural food colorants.

Lipid Metabolism Regulation by Unripe R. coreanus Extract

Unripe R. coreanus extract demonstrated the ability to reduce cholesterol synthesis in human liver cells, offering insights into its hypolipidemic action.

Anti-inflammatory Effects of R. coreanus Extracts

Extracts from different ripeness stages of R. coreanus fruits showed varying anti-inflammatory properties, with unripe fruit extracts being the most effective.

Antioxidant and Anti-angiogenic Activities

Methanol extract from R. coreanus inhibited VEGF binding to its receptor, indicating anti-angiogenic properties, while compounds from the fruit exhibited antinociceptive and anti-inflammatory effects.

Therapeutic Uses of Rubus Species

Various Rubus species, including R. coreanus, have been traditionally used for medicinal purposes and possess pharmacological properties such as antibacterial and anti-inflammatory effects.

Herb-Drug Interactions Involving R. coreanus

A herbal mixture containing R. coreanus showed minimal risk of interactions with drug metabolism mediated by cytochrome P450 enzymes.

Effects of R. coreanus on Erectile Function in Rats

An herbal formula including R. coreanus seeds enhanced erectile function in hypertensive male rats, possibly improving penile erection.

Anti-inflammatory and Anti-atherogenic Properties

Unripe R. coreanus fruit extract reduced atherosclerosis development in mice by improving blood lipid profiles and suppressing inflammation.

Curcumin and R. coreanus on Inflammatory Macrophages

Curcumin and unripe R. coreanus fruit extract showed anti-inflammatory effects on macrophages, with potential therapeutic applications.

Antioxidant and Antifatigue Effects

R. coreanus extracts demonstrated antioxidative properties and antifatigue effects in mice, suggesting benefits for endurance and recovery.

Osteoblast Function and R. coreanus Extract

R. coreanus extract promoted osteoblast activity and bone formation, offering potential for preventing osteoporosis and inflammatory bone diseases.

Immunomodulatory Effects of R. coreanus Nanoparticles

Nanoparticles containing R. coreanus extract showed enhanced immunomodulatory effects, stimulating immune cell activity and antibody production.

Allergic Inflammation and Anaphylaxis

Extracts from R. coreanus fruits showed potential in treating allergic inflammation and anaphylaxis by inhibiting mast cell-induced allergic reactions.

Antiviral Activities Against Hepatitis B Virus

Aqueous extracts from R. coreanus displayed antiviral properties against the hepatitis B virus, reducing viral DNA levels and antigen secretion.

Antiviral Effects of Black Raspberry Juice

Black raspberry juice, notably from R. coreanus, inhibited foodborne viral surrogates, suggesting its use in preventing viral outbreaks.

Reproductive Health Benefits

Studies on R. coreanus showed positive effects on male reproductive functions, including enhanced sperm count and testosterone levels.

Antioxidant Capacity in Humans

Supplementation with R. coreanus increased antioxidant enzyme activity in healthy men, demonstrating its potential to enhance antioxidant capacity.

Antioxidant Screening of Korean Herbs

Screening of 70 Korean herbs for antioxidant activities revealed R. coreanus as one of the most potent antioxidants.

Visual Processes and R. coreanus Extract

R. coreanus extract improved visual sensitivity in a bullfrog eye model, suggesting benefits for treating eye-related conditions.

Inhibition of Catecholamine Release

Polyphenolic compounds from R. coreanus inhibited catecholamine release in the rat adrenal medulla, hinting at cardiovascular benefits.

Prostate Cancer and R. coreanus Extract

R. coreanus ethanol extract exhibited anti-proliferative and pro-apoptotic effects on prostate cancer cells, especially those dependent on androgen.

Protective Effects Against Kidney Damage

Compounds from R. coreanus protected against kidney damage caused by chemotherapy, reducing oxidative stress and enhancing antioxidant defenses.

UV-B Protection for Skin

R. coreanus ethanol extract protected human dermal fibroblasts from UV-B induced collagen degradation, inhibiting MMP production.

Effects on Sperm Parameters and CREM Expression

R. coreanus improved rat sperm characteristics and increased CREM expression, essential for sperm production.

Role of the CREM Gene in Spermatogenesis

The CREM gene was found to be crucial for sperm development, with a switch from antagonist to activator isoforms during spermatogenesis.

References:

1. Dietary effect of Rubus coreanus ethanolic extract on immune gene expression in white leg shrimp, Penaeus vannamei
2. Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste
3. Characterization of seed oils from fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste
4. Optimization of the extraction of anthocyanin from Bokbunja (Rubus coreanus Miq.) marc produced during traditional wine processing and characterization of the extracts
5. Endothelium-independent relaxant effect of Rubus coreanus extracts in corpus cavernosum smooth muscle
6. What is the role of unripe Rubus coreanus extract on penile erection?
7. Anthocyanins in the ripe fruits of Rubus coreanus Miquel and their protective effect on neuronal PC-12 cells
8. Antiulcer activity of anthocyanins from Rubus coreanus via association with regulation of the activity of matrix metalloproteinase-2
9. Optimization of microwave-assisted extraction for anthocyanins, polyphenols, and antioxidants from raspberry (Rubus Coreanus Miq.) using response surface methodology
10. Water extracts of immature Rubus coreanus regulate lipid metabolism in liver cells
11. Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening
12. Immature Rubus coreanus Shows a Free Radical-Scavenging Effect and Inhibits Cholesterol Synthesis and Secretion in Liver Cells
13. Sanguiin H-6 blocks endothelial cell growth through inhibition of VEGF binding to VEGF receptor
14. Antinociceptive and antiinflammatory effects of Niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus
15. The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model
16. Therapeutic constituents and actions of Rubus species
17. Characterization of increased phenolic compounds from fermented Bokbunja (Rubus coreanus Miq.) and related antioxidant activity
18. Fatigue-alleviating effect on mice of an ethanolic extract from Rubus coreanus
19. Polyphenol compounds and anti-inflammatory activities of Korean black raspberry ( Rubus coreanus Miquel) wines produced from juice supplemented with pulp and seed
20. Anti-inflammatory and anti-superbacterial activity of polyphenols isolated from black raspberry
21. The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions
22. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats
23. Aqueous extract of unripe Rubus coreanus fruit attenuates atherosclerosis by improving blood lipid profile and inhibiting NF-κB activation via phase II gene expression
24. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages
25. Rubus coreanus inhibits oxidized-LDL uptake by macrophages through regulation of JNK activation
26. Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor
27. Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus
28. Antifatigue effect of Rubus coreanus Miquel extract in mice
29. Rubus coreanus Miq. extract promotes osteoblast differentiation and inhibits bone-resorbing mediators in MC3T3-E1 cells
30. Enhanced immunomodulatory activity of gelatin-encapsulated Rubus coreanus Miquel nanoparticles
31. Induction of heme oxygenase-1 mediates the anti-inflammatory effects of the ethanol extract of Rubus coreanus in murine macrophages
32. Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation
33. Action of Rubus coreanus extract on systemic and local anaphylaxis
34. Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus
35. Antiviral effects of black raspberry (Rubus coreanus) juice on foodborne viral surrogates
36. Fermentation filtrates of Rubus coreanus relax the corpus cavernosum and increase sperm count and motility
37. Effects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean men
38. Comparison of anti-oxidant activities of seventy herbs that have been used in Korean traditional medicine
39. Effects of Rubus coreanus extract on visual processes in bullfrog's eye
40. Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla
41. Chemopreventive effects of Rubus coreanus Miquel on prostate cancer
42. The ameliorative effect of 23-hydroxytormentic acid isolated from Rubus coreanus on cisplatin-induced nephrotoxicity in rats
43. 23-Hydroxytormentic acid and niga-ichgoside f₁ isolated from Rubus coreanus attenuate cisplatin-induced cytotoxicity by reducing oxidative stress in renal epithelial LLC-PK₁ cells
44. Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts
45. Effects of Rubus coreanus on sperm parameters and cAMP-responsive element modulator (CREM) expression in rat testes
46. Developmental switch of CREM function during spermatogenesis: from antagonist to activator
47. Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis

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