King Of Bitters (Andrographis paniculata): An Overview

1) Studied Conditions

The King Of Bitters has been studied for various conditions, including:

• Upper respiratory tract infections
• Common cold and flu
• Inflammatory conditions
• Gastrointestinal issues such as diarrhea and dysentery
• Immune system enhancement
• Liver protection and liver disorders

2) Efficacy in Treating Conditions

Research suggests that King Of Bitters may be effective in:

• Reducing the severity of symptoms associated with the common cold and flu
• Improving immune response
• Possibly aiding in the management of some inflammatory conditions

However, more research is needed to conclusively determine its efficacy for various conditions.

3) Health Benefits

King Of Bitters has been associated with several health benefits, including:

• Anti-inflammatory properties
• Antioxidant effects
• Stimulating the immune system
• Antimicrobial activity, potentially against certain bacteria and viruses
• Liver protection and hepatoprotective effects

4) Potential Downsides

While King Of Bitters has potential health benefits, there are also downsides to consider:

• Gastrointestinal discomfort, such as nausea or diarrhea, especially when taken in high doses
• Possible allergic reactions in sensitive individuals
• Interactions with medications, particularly those that are metabolized by the liver
• Not enough research to fully understand long-term effects and safety
• Should be used with caution during pregnancy and lactation due to insufficient safety data

5) Genetic Variations and Effects

Research on King Of Bitters and genetic variations is limited. However, some individuals may have genetic variations that affect:

• How their bodies metabolize herbal compounds
• Their susceptibility to allergic reactions
• Their immune system's response to herbal treatments

As of the current knowledge base, no specific genetic variations have been conclusively linked to a differential response to King Of Bitters. Consultation with a healthcare provider is recommended for personalized advice.

King Of Bitters (Andrographis paniculata) in Cancer Treatment and Respiratory Infections

Andrographis paniculata, commonly known as King Of Bitters, is a traditional medicinal plant used in Indian and Chinese medicine. Its bioactive compound, andrographolide, has shown anticancer properties, inducing cell-cycle arrest and apoptosis in cancer cells, and inhibiting angiogenesis in tumors. Research supports further exploration of andrographolide as a potential anticancer agent.

Effectiveness in Treating Respiratory Tract Infections

Andrographis paniculata has been found more effective than a placebo in reducing symptoms of uncomplicated upper respiratory tract infections (URTIs). The herb is generally safe, with mild and infrequent adverse events. The extract KalmCold, derived from this plant, significantly improved URTI symptoms, with an efficacy rate 2.1 times higher than the placebo.

Traditional Medicine and Modern Cancer Therapy

The integration of traditional Ayurvedic knowledge with modern scientific developments shows promise in cancer management. The screening of herbal compounds globally may contribute to finding potential anti-cancer drugs, with experimental and clinical studies demonstrating the scientific validity of Ayurvedic therapy for cancer treatment.

Studies on Andrographis paniculata

Various studies have measured the concentrations of active diterpenoids in different parts of the plant at various growth stages, providing insights for medicinal use optimization. Additionally, research has screened Chinese herbal plant extracts for substances that activate TRPV channels, finding bisandrographolide A (BAA) from Andrographis paniculata to potently activate TRPV4 channels.

Investigations into the safety and efficacy of Andrographis paniculata for treating upper respiratory tract infections and its potential as an anticancer agent have shown promising results, though more research is needed to confirm these benefits.

Conclusion

While it's premature to determine the compound's future role in cancer treatment, Andrographis paniculata shows potential as a treatment for symptom relief in upper respiratory tract infections and as a promising candidate for cancer treatment due to its anticancer and immunomodulatory effects.

References:

1. Andrographolide: a new plant-derived antineoplastic entity on horizon
2. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy
3. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection
4. Andrographis paniculata: a review of pharmacological activities and clinical effects
5. Cancer--an ayurvedic perspective
6. Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells
7. Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)
8. Bisandrographolide from Andrographis paniculata activates TRPV4 channels
9. New 2'-oxygenated flavonoids from Andrographis affinis
10. Flavones from the stem of Andrographis paniculata Nees
11. Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees
12. Determination of bioactive diterpenoids from Andrographis paniculata by micellar electrokinetic chromatography
13. Testicular toxicity assessment of Andrographis paniculata dried extract in rats
14. TRPV4 agonists and antagonists
15. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
16. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human
17. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein
18. A simple and sensitive HPLC-ESI-MS/MS method for the determination of andrographolide in human plasma
19. Four new andrographolide metabolites in human urine
20. Identification of a rare sulfonic acid metabolite of andrographolide in rats
21. [Studies on the structure of the adduct of andrographolide with sodium hydrogen sulfite (author's transl)]
22. In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19)
23. Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms
24. Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice
25. Chemokine-leukocyte interactions. The voodoo that they do so well
26. CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats
27. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria
28. Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts
29. Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway
30. Anticancer and immunostimulatory compounds from Andrographis paniculata
31. A phase I trial of andrographolide in HIV positive patients and normal volunteers
32. Undetectable anti-bacterial activity of Andrographis paniculata (Burma) wall. ex ness
33. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults
34. Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study
35. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection
36. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis
37. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children
38. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever
39. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial
40. Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats
41. Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells
42. Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice
43. In vitro assessment of paracetamol-induced toxicity in the rat Reuber hepatoma H4IIEC3/G(-) cell line competent of xenobiotics metabolism
44. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
45. Extracorporeal shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi
46. The usage of Andrographis paniculata following Extracorporeal Shock Wave Lithotripsy (ESWL)
47. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses
48. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses
49. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine
50. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis
51. The effect of Eurycoma longifolia on sperm quality of male rats
52. Antifertility effect of Andrographis paniculata (Nees) in male albino rat
53. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa
54. A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects
55. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata
56. Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation
57. Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach
58. The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway
59. Modulation of multidrug resistance by andrographolid in a HCT-8/5-FU multidrug-resistant colorectal cancer cell line
60. Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells
61. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide
62. Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in jurkat cells
63. Role of the Rb/E2F pathway in cell growth control
64. Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity
65. The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer
66. Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line
67. Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway
68. Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells
69. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells
70. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees
71. Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells
72. Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status

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