Hyaluronic Acid - NutraPedia

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Hyaluronic Acid Information

1) What conditions has it been studied for?

Hyaluronic acid has been studied for a number of conditions, including:

  • Osteoarthritis
  • Skin hydration and aging
  • Dry eye
  • Wound healing
  • Acid reflux
2) Does it work in treating those conditions?

Studies have shown mixed results:

  • For osteoarthritis: Injections of hyaluronic acid can provide pain relief and improved mobility in some patients.
  • For skin care: Topical applications are effective in hydrating the skin and reducing the appearance of fine lines and wrinkles.
  • For dry eye: Eye drops containing hyaluronic acid can be effective in reducing symptoms.
  • For wound healing: It can aid in the skin's healing process, but more research is needed.
  • For acid reflux: Limited evidence suggests it may provide some symptomatic relief.
3) What health benefits does it have?
  • Moisturizes skin
  • Promotes healthy, supple skin
  • Supports wound healing
  • Provides relief from osteoarthritis symptoms
  • Improves dry eye symptoms
4) Does it have any downsides?

While generally considered safe, there can be downsides:

  • Potential allergic reactions
  • Injection-related side effects such as pain, redness, and swelling
  • Oral supplements may not be as effective as topical or injectable forms
5) Is it beneficial or harmful for any particular genetic variations?

Research on genetic variations affecting hyaluronic acid efficacy is limited and inconclusive. Some studies suggest that individual responses to hyaluronic acid, especially in osteoarthritis treatment, may be influenced by genetic factors. However, more research is needed to determine specific genetic variations that may affect the benefits or risks of hyaluronic acid use.

Hyaluronic Acid Research Summary

Oral Hyaluronic Acid for Skin Wrinkles

A study revealed that oral hyaluronic acid (HA) reduced skin wrinkles in Japanese participants when administrated at 120 mg/day over 12 weeks, with significant improvements in the group taking HA with a molecular weight of 300 k.

HA Eye Drops for Dry Eye Syndrome

Meta-analysis research showed that HA eye drops are more effective than non-HA solutions in treating dry eye syndrome, as evidenced by improved tear production and Schirmer's test scores.

Topical HA and Skin Aging

Topically applied HA has been found to counteract signs of skin aging, which are affected by both age and environmental factors. HA cosmeceuticals demonstrated clinical benefits in skin hydration and rejuvenation.

HA in Combination with BoNTA Injections

A randomized controlled trial indicated that a HA-filler serum could prolong the anti-wrinkle effects of Botulinum toxin type A (BoNTA) injections over 24 weeks.

Medical Applications of Hyaluronic Acid

A systematic review emphasized HA's therapeutic properties, such as moisturizing and pain-relieving effects, and its application in treating osteoarthritis, ophthalmological conditions, and dermatology concerns with minimal side effects.

HA vs. Corticosteroids for Knee Osteoarthritis

HA provides long-term pain relief in knee osteoarthritis, outperforming corticosteroids, despite a higher incidence of local side effects.

HA Injections for Soft Tissue Injuries

HA injections were generally more effective than placebos and other active treatments for various soft tissue conditions, although more research is needed to confirm these findings.

HA Injections for Frozen Shoulder

While HA injections did not significantly outperform other treatments for pain control in frozen shoulder, they contributed to improved functional recovery in external rotation.

Physicochemical Properties of HA Fillers

Understanding the diverse properties of HA fillers can help clinicians achieve better facial rejuvenation outcomes by selecting appropriate fillers for specific treatment areas.

HA Derivatives in Wound Healing

HA derivatives were found to significantly improve wound healing across various conditions, including burns and chronic wounds, compared to traditional treatments.

HA and Inflammation Therapy

HA has been studied for its potential in treating inflammatory diseases, with evidence supporting its effectiveness in pain relief.

Ag NPs and HA for Antimicrobial Use

HA-modified silver nanoparticles (Ag NPs) demonstrated effective antibacterial properties with reduced toxicity to human skin cells.

HA Derivatives in Medical and Pharmaceutical Applications

HA derivatives have been used in various medical fields, including tissue regeneration and cancer treatment, due to their anti-inflammatory effects and ability to prolong HA's longevity in human tissues.

HA Fillers for Hair Growth

A noncrosslinked HA filler showed potential in stimulating hair growth by protecting dermal papilla cells from oxidative stress and promoting vascular endothelial growth factor (VEGF) release.

Oral HA for Skin Hydration

Orally ingested HA improved skin moisture, elasticity, and reduced wrinkles over a 12-week period in a placebo-controlled study.

Low-Molecular-Weight HA in Cosmetics

A study found that 50-kDa low-molecular-weight HA penetrated the skin effectively without causing inflammation, suggesting its suitability as a cosmetic ingredient.

Management of HA Filler Complications

The Global Aesthetics Consensus Group developed recommendations to prevent and manage complications from HA fillers, emphasizing the importance of clinical expertise in application techniques.

Dry Eye Disease Management

A review by the Management and Therapy Subcommittee highlighted a need for more research to support various treatments for dry eye disease and proposed a step-by-step management algorithm.


  1. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period
  2. A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome
  3. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
  4. Physiochemical properties and application of hyaluronic acid: a systematic review
  5. Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: A meta-analysis
  6. The Role of Hyaluronic Acid for Soft Tissue Indications: A Systematic Review and Meta-Analysis
  7. The Effect of Intra-articular Injection of Hyaluronic Acid in Frozen Shoulder: a Systematic Review and Meta-analysis of Randomized Controlled Trials
  8. Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance
  9. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials
  10. Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation
  11. Hyaluronic Acid Derivative Molecular Weight-Dependent Synthesis and Antimicrobial Effect of Hybrid Silver Nanoparticles
  12. Hyaluronic Acid: Redefining Its Role
  13. In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
  14. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study
  15. Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
  16. Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers-Evidence- and Opinion-Based Review and Consensus Recommendations
  17. TFOS DEWS II Management and Therapy Report

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