Cissus Quadrangularis - NutraPedia

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Cissus Quadrangularis Overview

1) What conditions has it been studied for?

Cissus Quadrangularis has been studied for various conditions, including:

  • Bone fractures and osteoporosis.
  • Gastrointestinal disorders like ulcers and gastritis.
  • Weight loss and obesity management.
  • Joint pain and inflammation, including conditions like arthritis.
  • Diabetes and related metabolic disorders.
  • Antioxidant and anti-inflammatory properties for overall health benefits.

2) Does it work in treating those conditions?

Research indicates that Cissus Quadrangularis may be effective in:

  • Accelerating bone healing in fractures and improving bone health in osteoporosis.
  • Reducing symptoms of gastrointestinal disorders.
  • Aiding in weight loss and obesity management, though results may vary.
  • Relieving joint pain and inflammation.
  • Improving blood sugar control in diabetes.

3) What health benefits does it have?

Health benefits of Cissus Quadrangularis include:

  • Enhancing bone health and accelerating fracture healing.
  • Alleviating pain and inflammation in joints.
  • Gastroprotective effects, helping in treating ulcers and gastritis.
  • Weight management and potential anti-obesity effects.
  • Antioxidant properties, protecting against oxidative stress.
  • Potential blood glucose regulation benefits.

4) Does it have any downsides?

Potential downsides of Cissus Quadrangularis include:

  • Possible side effects like headache, intestinal gas, dry mouth, diarrhea, and insomnia.
  • Interactions with other medications, especially those for diabetes and blood sugar control.
  • Limited research on its long-term safety and side effects in humans.

5) Is it beneficial or harmful for any particular genetic variations?

Currently, there is limited research on the interaction of Cissus Quadrangularis with specific genetic variations. Therefore, its benefits or harms may not be clearly associated with any particular genetic profiles.

Key Research Points:

  • Genotoxic and Mutagenic Activity: Genotoxic effects of various foods and food components, including Cissus quadrangularis, on Swiss mice. Cissus quadrangularis showed moderate genotoxic effects, comparable to certain other substances.
  • Antifungal and Cytotoxic Activities: A study on the antifungal potential and cytotoxicity of Cissus quadrangularis showed that its extracts were effective against fungi and had certain cytotoxic effects on specific cell lines.
  • Pharmacological Activities: Applications in bone regeneration, ulcer treatment, pain relief, and anti-inflammatory properties.
  • Gastroprotective Effects: There's a focus on the gastroprotective effect of Cissus quadrangularis extract in rats, particularly against aspirin-induced ulcers. The plant extract was found to prevent gastric mucosal lesion development and decrease gastric toxicity.
  • Analgesic, Anti-inflammatory, and Venotonic Effects: The plant has been studied for its analgesic and anti-inflammatory activities and its effectiveness in treating hemorrhoids. It exhibits properties that reduce pain and inflammation and has venotonic effects.
  • Mutagenic, Cytotoxic, and Apoptotic Activities: A study evaluated the mutagenic and cytotoxic activities of Cissus quadrangularis, particularly focusing on liver cells, revealing that it is not mutagenic or cytotoxic in human hepatic cells.
  • Liver Injury Treatment: Effect of Cissus quadrangularis on acetaminophen-induced liver injury, suggesting its potential in treating liver diseases.
  • Management of Metabolic Syndrome: Cissus quadrangularis has been studied for its effects on weight reduction and improving blood parameters related to metabolic syndrome.
  • Insulin Resistance and Liver Disease: The extract of Cissus quadrangularis stem was evaluated for its protective effects against insulin resistance and oxidative injury in liver disease.
  • Bone Tissue Engineering: Role of Cissus quadrangularis in bone tissue engineering, particularly in osteogenesis and biomineralization.
  • Anxiolytic and Antiepileptic Properties: The plant was also studied for its anxiolytic and antiepileptic properties, showing potential in treating epilepsy and reducing anxiety.
  • Osteoclastogenesis and Bone Health: The plant's potential in treating osteoporosis and its ability to modulate the host immune system to improve bone health.
  • Efficacy and Safety Evaluation: A comprehensive review and evaluation of the efficacy and safety of Cissus quadrangularis extracts are included, covering its various medicinal uses and safety profile.

Overall, the papers below provide an extensive examination of the various medicinal applications and health benefits of Cissus quadrangularis, highlighting its potential in treating a wide range of conditions from bone and liver diseases to metabolic syndrome and neurological disorders.


  1. Genotoxic effects of some foods & food components in Swiss mice
  2. Mutagenic activity of south Indian food items
  3. Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
  4. A short review on pharmacological activity of Cissus quadrangularis
  5. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer
  6. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn
  7. Evaluation of mutagenic, cytotoxic, mitochondrial dysfunction, apoptotic activity, and acute toxicity of ethanolic extract of Cissus quadrangularis
  8. Potential Curative Effects of Aqueous Extracts of Cissus quadrangularis (Vitaceae) and Jatropha gossypiifolia (Euphorbiaceae) on Acetaminophen-Induced Liver Injury in Mice
  9. The Use of Cissus quadrangularis (CQR-300) in the Management of Components of Metabolic Syndrome in Overweight and Obese Participants
  10. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet
  11. In vitro biomineralization and osteogenesis of Cissus quadrangularis stem extracts: An osteogenic regulator for bone tissue engineering
  12. Anxiolytic and Antiepileptic Properties of the Aqueous Extract of Cissus quadrangularis (Vitaceae) in Mice Pilocarpine Model of Epilepsy
  13. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts
  14. Cissus quadrangularis L. extract attenuates chronic ulcer by possible involvement of polyamines and proliferating cell nuclear antigen
  15. Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells
  16. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study
  17. Cissus quadrangularis attenuates the adjuvant induced arthritis by down regulating pro-inflammatory cytokine and inhibiting angiogenesis
  18. Hepatoprotective Effect of Cissus quadrangularis Stem Extract Against Rifampicin-induced Hepatotoxicity in Rats
  19. Cissus quadrangularis (Hadjod) Inhibits RANKL-Induced Osteoclastogenesis and Augments Bone Health in an Estrogen-Deficient Preclinical Model of Osteoporosis Via Modulating the Host Osteoimmune System
  20. A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts
  21. Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta-analysis of Randomized Controlled Trials
  22. Cissus quadrangularis extract mitigates diabetic cardiomyopathy by inhibiting RAAS activation, inflammation and oxidative stress
  23. Role of Cissus quadrangularis in the Management of Osteoporosis: An Overview
  24. Cissus quadrangularis L: A comprehensive multidisciplinary review
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