Centrophenoxine - NutraPedia

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Centrophenoxine Overview

1) Conditions Studied

Centrophenoxine has been studied for a variety of conditions, primarily related to cognitive health and aging. Some of the conditions include:

  • Age-related memory impairment
  • Alzheimer's disease and other forms of dementia
  • Cognitive decline associated with aging
  • Brain injury recovery

2) Efficacy in Treating Conditions

Research on centrophenoxine's effectiveness for treating these conditions has yielded mixed results. While some studies suggest potential benefits in improving memory and cognitive function, especially in older individuals, the evidence is not conclusive. More rigorous and extensive clinical trials are needed to ascertain its therapeutic efficacy.

3) Health Benefits

Some of the reported health benefits of centrophenoxine include:

  • Enhancement of cognitive function
  • Improvement in memory recall and learning ability
  • Potential neuroprotective effects
  • Increased brain energy metabolism
  • Reduction in lipofuscin (age pigment) in neural tissues

4) Potential Downsides

While centrophenoxine is generally considered safe for most people, it can have downsides, including:

  • Gastrointestinal discomfort
  • Headaches
  • Dizziness
  • Irritability
  • Insomnia, particularly when taken in high doses or late in the day
  • Potential for interaction with other medications

It is important to consult a healthcare professional before starting centrophenoxine, especially for individuals with pre-existing health conditions or those taking other medications.

5) Genetic Variations and Centrophenoxine

There is limited research on the interaction between centrophenoxine and specific genetic variations. Some individuals may metabolize and respond to centrophenoxine differently due to their genetic makeup. However, as of the current knowledge cutoff, there is no widely recognized evidence that suggests centrophenoxine is particularly beneficial or harmful for specific genetic variations. Those considering centrophenoxine supplementation may want to discuss genetic testing with their healthcare provider to tailor their approach to cognitive health and supplementation.

Centrophenoxine Research Summary

Effects on Aging in Rat Hippocampus

A study on male Wistar rats revealed that aging leads to increased lipid peroxidation and lipofuscin concentration in the hippocampus, particularly in the CA3 region. This was correlated with a decline in neuronal electrical activity. Centrophenoxine treatment in older rats (16-24 months) significantly reduced these signs of aging and improved neuronal function by increasing multiple unit activity (MUA).

Impact on Human Glial Cells

Research on human glial cells demonstrated that meclofenoxate, a form of centrophenoxine, decreases lipofuscin accumulation, enhancing the cells' metabolic functions. This includes increased RNA and protein synthesis, and glucose uptake, suggesting a redirection of glucose usage that could slow down the aging process in vitro.

Influence on Cerebral Metabolism

A study on the perfused cat brain assessed various cerebral metabolic activators. Results showed that cytidine monophosphate and citicoline positively influenced glucose metabolism in the brain, with citicoline also increasing cerebral blood flow and reducing lactate accumulation. However, pyrithioxin and meclofenoxate had no significant impact on these parameters.

Clinical Trial in Elderly with Dementia

A double-blind clinical trial with 50 elderly participants with moderate dementia tested the effects of centrophenoxine (CPH). After an initial placebo phase, participants were treated with 2 grams per day of CPH or a placebo for 8 weeks. The CPH group showed improvements in psychometric tests and a significant increase in intracellular water content, supporting centrophenoxine's potential as a free radical scavenger and its role in the membrane hypothesis of aging.

References:


  1. Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine
  2. [Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate]
  3. Effects of various cerebral metabolic activators on glucose metabolism of brain
  4. Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial


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