Celery Seed Extract Information

1. Studied Conditions

Celery seed extract has been studied for a variety of conditions, including:

• High blood pressure (hypertension)
• Inflammatory disorders such as arthritis
• Urinary tract infections
• Gout
• Cholesterol management

2. Efficacy in Treating Conditions

The effectiveness of celery seed extract in treating these conditions varies:

• Some studies suggest it may help lower blood pressure and reduce inflammation.
• Its diuretic properties may aid in the treatment of urinary tract infections.
• However, evidence is limited and more research is needed to confirm these findings.

3. Health Benefits

Celery seed extract is associated with several potential health benefits:

• May reduce inflammation and pain associated with arthritis.
• Potential to lower blood pressure in hypertensive individuals.
• Diuretic effects could promote kidney health by aiding in the elimination of excess fluid.
• Contains antioxidants that may protect against oxidative stress and support overall health.

4. Downsides

While celery seed extract is generally considered safe, there are some potential downsides:

• May interact with certain medications, such as blood thinners and diuretics.
• Possible allergic reactions in individuals sensitive to celery or other plants in the Apiaceae family.
• Excessive consumption could lead to skin inflammation or photosensitivity.
• Insufficient safety data for pregnant or breastfeeding women, so they should avoid it.

5. Genetic Variations

The impact of celery seed extract on specific genetic variations is not well-documented:

• Currently, there is limited research on the interaction between celery seed extract and genetic variations.
• Some individuals may metabolize celery seed compounds differently due to genetic differences, which could affect efficacy and safety.
• Further research is needed to understand how genetic variations may influence the benefits or risks of celery seed extract.

Effects and Therapeutic Potential of Celery Seed Extract

Celery Seed Extract Mitigating DEHP Toxicity: A study found that celery seed oil extract (Apium graveolens) at 50 µl/kg reduced the toxic effects of DEHP, a plasticizer, in rats. The extract improved lipid profiles, liver function, and vascular oxidative stress, suggesting its potential in counteracting DEHP toxicity.

Protective Effects on Liver: Methanolic extracts from celery seeds showed significant protection against liver damage induced by harmful substances in rats, indicating their use in traditional Indian medicine for liver diseases.

Gastric Lesions and Antibacterial Activity: Celery extracts reduced gastric lesions in rats and showed antibacterial activity against certain bacteria, comparable to the standard drug omeprazole, highlighting its potential for treating ulcers and bacterial infections.

Antifungal Properties: Celery seed extract demonstrated strong antifungal effects against various plant pathogenic fungi and may serve as a natural treatment option for fungal infections.

Induction of Apoptosis in Cancer Cells: Celery seed extract induced apoptosis and inhibited cell proliferation in human stomach cancer cells by affecting the cell cycle and protein expression related to apoptosis.

Anti-Cancer Compounds in Celery Seed Oil: Compounds in celery seed oil, particularly 3-n-butyl phthalide and sedanolide, were found to reduce tumor incidence in mice, suggesting their role in cancer prevention.

Toxicological Safety of Celery Seed Extract: An alcoholic celery seed extract did not show toxic effects in a 28-day rat study, even at high doses, indicating its safety for consumption.

References:

1. The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity
2. Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats
3. Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A
4. Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract
5. Ligustilide: a novel TRPA1 modulator
6. Advances in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese Danggui)
7. Analysis of volatile oil in Rhizoma ligustici chuanxiong-Radix paeoniae rubra by gas chromatography-mass spectrometry and chemometric resolution
8. Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity
9. Phytopathogenic fungal inhibitors from celery seeds
10. Dynamic nature of the ligustilide complex
11. Plastics and health risks
12. Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly
13. Beneficial role of celery oil in lowering the di(2-ethylhexyl) phthalate-induced testicular damage
14. Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line
15. Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil
16. Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines
17. A toxicological investigation of a celery seed extract having anti-inflammatory activity

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