Celastrus Paniculatus Overview
1) Conditions Studied
Celastrus paniculatus, also known as the "intellect tree," has been traditionally used in Ayurvedic medicine and studied for various conditions, including:
- Cognitive disorders and memory enhancement
- Neuroprotective effects
- Depression and anxiety
- Antioxidant properties
- Anti-inflammatory effects
2) Efficacy in Treating Conditions
While traditional use suggests potential benefits, scientific evidence on the efficacy of Celastrus paniculatus in treating these conditions is still limited and more rigorous studies are needed. Some preliminary studies suggest cognitive enhancement and neuroprotective effects, but clinical outcomes vary.
3) Health Benefits
Some of the purported health benefits of Celastrus paniculatus include:
- Enhancement of cognitive function and memory
- Potential neuroprotection against diseases like Alzheimer's
- Antidepressant and anxiolytic properties
- Antioxidant effects that may protect against cellular damage
- Anti-inflammatory properties that may help with various inflammatory conditions
4) Downsides
While Celastrus paniculatus is generally considered safe, there can be downsides, including:
- Possible side effects such as gastrointestinal disturbances
- Lack of extensive clinical trials to fully understand safety and efficacy
- Potential for interactions with other medications
- Quality and purity of supplements may vary between products
5) Effects on Genetic Variations
There is limited research on the interaction between Celastrus paniculatus and specific genetic variations. As with any herbal supplement, individual responses can vary, potentially influenced by genetic factors. However, conclusive evidence is currently lacking in this area, and personalized genetic considerations remain a topic for future research.
Research Summary on Celastrus Paniculatus
Antioxidant and Antistress Effects
Celastrus paniculatus seed oil, also known as Jyothismati oil, has been demonstrated to improve antioxidant enzyme levels in mice subjected to immobilization stress, suggesting its potential to mitigate health issues associated with limited movement.
Antidepressant-like Effects
The seed oil shows significant antidepressant-like effects in mice, comparable to fluoxetine, and involves the inhibition of MAO-A activity, reduction in corticosterone levels, and interaction with various neurotransmitter receptors.
Neuroprotective Effects
Studies on rat forebrain neuronal cells indicate that Celastrus paniculatus seed oil and extracts possess neuroprotective properties, offering protection against cell damage from oxidative stress and glutamate toxicity.
Anticancer Activity
A sesquiterpene compound isolated from the plant significantly reduces the viability of breast cancer cells, suggesting potential antiproliferative effects.
Memory and Learning Improvement
The seed extract improves memory and learning in animal models, likely through mechanisms involving increased acetylcholine levels in the brain.
Alzheimer's Disease Protection
Seed oil from Celastrus paniculatus may slow down Alzheimer's-like pathological processes in rats induced by aluminum.
Cognitive Enhancing Properties
Water-soluble extracts from the seeds have shown to protect neuronal cells from glutamate-induced damage and to enhance cognitive functions in rats.
Cholesterol-lowering Effects
Methanolic extract from the seeds has a hypolipidemic effect, lowering cholesterol and triglycerides levels in rats with induced hypercholesterolemia.
Anxiolytic Activity
Celastrus oil has shown significant anxiolytic activity in rat models, potentially influencing the serotonin system.
Free Radical Scavenging
Extracts from Celastrus paniculatus, among other medicinal plants, exhibit dose-dependent capabilities to neutralize free radicals and protect against DNA damage.
Antifertility and Liver Health Impact
The seed oil has shown antifertility properties in male rats, but also caused reversible liver changes.
Intestinal Spasm Treatment
Celastrus paniculatus seed extract displays a strong relaxant effect on the ileum, supporting its traditional use in treating intestinal spasms.
References:
- Effect of Celastrus paniculatus seed oil (Jyothismati oil) on acute and chronic immobilization stress induced in swiss albino mice
- Behavioral and Biochemical Evidences for Antidepressant-Like Activity of Celastrus Paniculatus Seed Oil in Mice
- Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells
- Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells
- Identification of a new sesquiterpene polyol ester from Celastrus paniculatus
- New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus
- Nootropic activity of Celastrus paniculatus seed
- Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study
- Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain
- Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus
- Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats
- Effect of Celastrus paniculatus seed extract on the brain of albino rats
- The toxicology of aluminum in the brain: a review
- Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?
- Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities
- Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour
- Antioxidant property of Celastrus paniculatus willd.: a possible mechanism in enhancing cognition
- Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats
- Indian medicinal plants as antiradicals and DNA cleavage protectors
- Antispermatogenic action of Celastrus paniculatus seed extract in the rat with reversible changes in the liver
- Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum
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