Caralluma Fimbriata: An Overview

1. Conditions Studied

Caralluma Fimbriata has been primarily studied for its potential effects on weight loss, appetite suppression, and overall metabolic health. It has also been explored for its possible benefits in controlling obesity, diabetes, and other metabolic syndromes.

2. Effectiveness in Treating Conditions

Research on Caralluma Fimbriata suggests that it may have some benefits in suppressing appetite and aiding in weight loss. However, the results are mixed, and more rigorous scientific studies are required to conclusively determine its effectiveness for these conditions. As with any supplement, individual results may vary.

3. Health Benefits

• May aid in weight loss
• Potentially suppresses appetite
• Could enhance endurance
• Might have anti-inflammatory properties

4. Potential Downsides

While Caralluma Fimbriata is generally considered safe when taken as directed, some individuals might experience side effects such as stomach upset, intestinal gas, constipation, or other gastrointestinal issues. Long-term safety and potential interactions with medications have not been extensively studied.

5. Genetic Variations and Effects

Currently, there is limited research on the relationship between genetic variations and the effects of Caralluma Fimbriata. It is not well established whether certain genetic profiles may benefit more or less from its use or whether there are any specific genetic risk factors associated with its consumption. Personal genetic differences can influence how individuals metabolize and respond to supplements, so it is always advisable to consult with a healthcare provider before starting any new supplement regimen.

Caralluma Fimbriata: A Potential Natural Appetite Suppressant

Study on Overweight Adults

A placebo-controlled trial on 50 overweight adults showed that those who took 1 gram of Caralluma fimbriata extract daily for 60 days experienced a significant reduction in waist circumference and hunger levels compared to the placebo group. There was also a trend towards decreases in body weight, BMI, hip circumference, body fat, and energy intake in the Caralluma group, although not statistically significant.

Chemical Compounds in Caralluma Fimbriata

The research identified eleven new pregnane glycosides from the Caralluma adscendens var. fimbriata, with compounds 10-13 having a unique structure. These compounds were analyzed using 2D-NMR spectroscopy.

Caralluma Genus and Traditional Uses

The Caralluma genus, with over 260 species, is used traditionally to treat ailments like rheumatism and diabetes. In particular, Caralluma fimbriata is recognized as safe (GRAS) in the US for combating obesity due to its appetite-suppressing qualities. The pregnane glycosides in Caralluma, similar to those in Hoodia, have anti-obesity properties. An example product is Slimaluna®, used for weight management.

Quantification of Pregnanes in Caralluma

An HPLC method was developed to quantify five pregnane derivatives in Caralluma species and dietary supplements. The method showed good linearity and repeatability, with detection and quantification limits ranging from 1-5 micrograms per milliliter and 3-15 micrograms per milliliter, respectively.

Effects of Caralluma Fimbriata Extract on Obesity

A study using a Diet-Induced Obesity (DIO) rat model found that Caralluma fimbriata extract (CFE) significantly reduced food intake and prevented increases in body and liver weight, and fat pad mass. It also improved serum lipid profiles, reduced serum leptin levels, and provided protection against atherosclerosis, suggesting potential anti-obesity and anti-atherosclerotic benefits.

Appetite-Suppressing Effects of P57AS3

The compound P57AS3, derived from Hoodia gordonii, was found to increase ATP levels in hypothalamic neurons and reduce food intake by 40-60% over 24 hours when injected into the brain, suggesting a potential mechanism for appetite suppression.

References:

1. Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women
2. Pregnane glycosides from Caralluma adscendens var. fimbriata
3. Pharmacological review of Caralluma R.Br. with special reference to appetite suppression and anti-obesity
4. Quantitative determination of pregnanes from aerial parts of Caralluma species using HPLC-UV and identification by LC-ESI-TOF
5. Further constituents from Caralluma negevensis
6. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract
7. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!