1. What conditions has Calcium Salts been studied for?

• Enteric hyperoxaluria (often after fat malabsorption from intestinal resection/bypass or malabsorptive bariatric surgery), to bind dietary oxalate in the gut and reduce urinary oxalate.

• Dental enamel demineralisation/remineralisation, as additives to oral care products to enhance fluoride delivery/retention and/or provide calcium for remineralisation.

• Food processing / contaminant mitigation: reduction of acrylamide formation in bakery products (a food safety/processing application rather than a clinical condition).

• Population calcium deficiency (low intake leading to nutritional rickets in children and osteomalacia in adults), via calcium fortification of foods.

• Pathologic calcification disorders where insoluble calcium salts deposit in tissues, including:

  • Calcinosis cutis (dystrophic, metastatic, idiopathic, iatrogenic, calciphylaxis subtypes).

  • Dermatomyositis-associated calcinosis (especially juvenile dermatomyositis, also adult DM).

  • Vascular calcification (calcium salt accumulation in vessel walls; mechanistic studies discussed in the studies).

  • Renal failure–related mineral trafficking (vascular calcification alongside skeletal mineral loss; conceptual/mechanistic discussion).

• Dentistry materials science: formation of resin monomer–calcium salts (e.g., 10-MDP–Ca) at the resin–dentin interface and its relationship to bond durability (not a supplement use, but a studied calcium-salt interaction).

2. Does it work in treating those conditions? Summarize the evidence.

• Enteric hyperoxaluria: The studies describe calcium salts as the primary medical intervention used as oral oxalate-binding agents to reduce free intestinal oxalate and thereby reduce absorption and urinary oxalate. However, a systematic review notes that evidence for clinically significant outcomes (e.g., fewer kidney stone events or prevention of CKD progression) is currently lacking. Overall: mechanistically plausible and commonly used, but limited outcomes evidence in the studies reviewed here.

• Tooth remineralisation/enamel protection: The review concludes fluoride treatments are generally effective, and that adding calcium salts/materials to oral care products may enhance delivery/retention of fluoride and may act as additional calcium sources to promote remineralisation or reduce demineralisation. Overall: supportive rationale and body of research, but the study does not quantify clinical effect sizes for calcium salts specifically.

• Calcium fortification to address low intake (rickets/osteomalacia risk): The landscape review supports fortification as a strategy to improve intake, but highlights practical limitations (notably bioavailability ~20–40% for calcium salts and the need for larger added amounts). The study does not provide direct trial evidence of reduced rickets/osteomalacia incidence, but frames fortification as a plausible public health approach with implementation constraints.

• Acrylamide reduction in bakery products: The food-safety review lists calcium salts among approaches used to reduce acrylamide levels in bakery products. The study does not provide quantitative reductions or comparative effectiveness, but indicates calcium salts are part of established mitigation strategies.

• Calcinosis cutis / dermatomyositis calcinosis / vascular calcification: In these contexts, calcium salts are the deposited material (a pathologic endpoint), not a treatment. The dermatomyositis abstract focuses on mechanisms and biomarkers; the vascular calcification abstract focuses on a regulatory pathway (nesfatin-1/BMP-2/Smad/RUNX2/OPN) and potential inhibitors of nesfatin-1, not calcium salt therapy.

• Resin–dentin bond durability (10-MDP–Ca nanolayering): The study found nanolayering with 10-MDP but concluded it is unlikely to contribute to overall bond durability because both 10-MDP and an analog showed similar bond strength decline after one-year water aging. This is not a clinical “treatment” outcome for calcium salts, but it is evidence about a proposed benefit of calcium-salt nanolayering in dental adhesives.

3. What health benefits does it have?

• Reduced intestinal oxalate absorption (enteric hyperoxaluria): Calcium salts can bind oxalate in the gut, lowering free oxalate available for absorption—mechanistically aimed at reducing hyperoxaluria-associated risk of kidney stones and oxalate nephropathy (though the studies note limited evidence on hard outcomes).

• Potential support for enamel remineralisation and caries prevention strategies: Calcium salts/materials in oral care products may provide additional calcium and may enhance fluoride delivery/retention, supporting remineralisation and reducing demineralisation processes.

• Improving calcium intake at the population level: Fortification with calcium salts could help address widespread low calcium intake, which is associated with nutritional rickets in children and osteomalacia in adults.

• Indirect public health benefit via food safety: Use of calcium salts in bakery processing may reduce acrylamide formation, potentially lowering dietary exposure to a compound described as neurotoxic, genotoxic, carcinogenic (IARC group 2A), and reproductively toxic.

4. Does it have any downsides or side effects?

• Evidence gaps for clinical outcomes (enteric hyperoxaluria): While calcium salts are used to bind oxalate, the systematic review notes that evidence is lacking for effects on clinically significant outcomes (kidney stone events, CKD). This is a limitation rather than a side effect, but it affects confidence in net benefit.

• Fortification challenges and potential overconsumption risk: The fortification review notes:

  • Low bioavailability (~20–40%) of calcium salts, requiring larger additions to foods to meaningfully impact intake.

  • Organoleptic/technical issues: changes in flavor, color, appearance; solubility challenges in liquids and acidic foods.

  • Cost: calcium salts may account for 70–90% of total fortification cost.

  • Safety monitoring is emphasized to avoid exceeding recommended intake when adding calcium broadly to the food supply.

• Pathologic calcium salt deposition (harmful in disease contexts): Multiple studies describe calcium salts as the material deposited in harmful ectopic calcification states:

  • Calcinosis cutis (including iatrogenic calcinosis cutis as a therapy side effect in general, though not specifically tied to calcium salt supplementation in the study).

  • Dermatomyositis-associated calcinosis, with deposits in skin, subcutaneous tissue, tendons, fascia, and muscle.

  • Vascular calcification, associated with increased cardiovascular events and mortality.

  These studies do not establish that dietary calcium salts cause these conditions, but they underscore that calcium salt deposition itself can be pathogenic in certain diseases and metabolic disturbances.

5. Is it beneficial or harmful for any genetic variations (pharmacogenomics)?

The studies reviewed here do not identify specific genetic variants that predict benefit or harm from calcium salts used as supplements, fortificants, or oxalate binders.

• Dermatomyositis calcinosis: The review notes that genetic and inflammatory markers and myositis autoantibodies have been studied as potential biomarkers for calcinosis risk in juvenile and adult dermatomyositis, but the study does not name actionable genetic variants or link them to response to calcium salt interventions.

• Vascular calcification: The mechanistic study identifies a signaling pathway (STAT3-driven nesfatin-1 expression; downstream BMP-2/Smad/RUNX2/OPN) and natural compounds that inhibit nesfatin-1, but it does not describe pharmacogenomic modifiers of calcium salt effects.

Overall, based on these studies, there is insufficient pharmacogenomic evidence to conclude that calcium salts are specifically beneficial or harmful in defined genetic subgroups.

Calcium carbonate

Across the studies, calcium carbonate (CaCO₃) research clusters into several heavily studied domains: (1) clinical supplementation and mineral metabolism (notably chronic kidney disease and pregnancy), (2) long-term population outcomes of calcium carbonate–based supplementation (often combined with vitamin D), (3) oral health applications as an inorganic, remineralizing/buffering ingredient in biofilm-active formulations, and (4) materials/engineering and biomedical nanotechnology, including calcium carbonate nanoparticles for drug delivery/theranostics and microbial-induced calcium carbonate precipitation (MICP) for environmental remediation. A parallel mechanistic literature focuses on amorphous calcium carbonate (ACC) as a biomineral precursor, examining how water and additives (e.g., Mg-containing species, poly(aspartic acid)) modulate stability, crystallization pathways, and energetics.

The strongest evidence in these studies is clinical and population-based. In stage 3–4 CKD, controlled metabolic balance data indicate that calcium carbonate used as a phosphate binder can rapidly induce positive calcium balance without meaningfully improving phosphorus balance over weeks, with kinetic signals suggesting that some retained calcium may deposit in soft tissues—findings that raise safety concerns if sustained long term. In pregnancy, policy guidance supported by broader evidence (as summarized) indicates calcium supplementation (commonly as calcium carbonate) reduces preeclampsia risk in settings with low habitual calcium intake, with practical dosing recommendations emphasizing divided doses. In older women, long-term follow-up of a large randomized trial of calcium carbonate plus vitamin D suggests small but measurable shifts in cause-specific mortality (lower cancer mortality and higher cardiovascular mortality) with no net effect on all-cause mortality, underscoring that benefits and risks may differ by outcome and that combined supplementation complicates attribution to calcium carbonate alone.

Key research gaps include: (1) longer-term, adequately powered CKD trials that directly link calcium balance/soft-tissue deposition signals to clinical endpoints (vascular calcification, cardiovascular events) and compare calcium carbonate with non-calcium phosphate binders; (2) mechanistic and trial designs that disentangle calcium carbonate effects from vitamin D and from background personal supplement use in population studies, and that clarify which subgroups experience net benefit versus harm; (3) stronger clinical effectiveness evidence for oral-care formulations containing calcium carbonate beyond surrogate measures (e.g., caries incidence and periodontal outcomes in pragmatic trials); and (4) translational work for CaCO₃ nanoparticles and MICP that moves from proof-of-concept toward standardized manufacturing, safety/toxicology, biodistribution, and real-world performance, alongside deeper mechanistic understanding of ACC stabilization/crystallization under biologically relevant additive and hydration conditions.

Calcium supplements

Research on calcium supplements has been most extensively focused on skeletal outcomes in adults over 50 (bone mineral density [BMD] and fracture prevention), with large randomized controlled trials (RCTs) and meta-analyses comparing supplements (often with co-administered vitamin D) versus placebo, and fewer trials evaluating increased calcium from dietary sources. A second well-studied area is cardiovascular safety, including reanalyses of large trials (e.g., WHI CaD) and pooled trial-level meta-analyses assessing myocardial infarction and stroke. More specialized clinical contexts are also represented, such as the use of calcium supplementation to bind intestinal oxalate in secondary hyperoxaluria/oxalate nephropathy, and adjunctive use in premenstrual disorders, though these areas are less dominated by large, calcium-specific RCT evidence.

The strongest evidence indicates that increasing calcium intake—via diet or supplements—produces small, non-progressive increases in BMD (generally ~0.6–1.8% depending on site and duration), with limited likelihood of translating into large, clinically meaningful fracture risk reductions for most community-dwelling older adults. Evidence that calcium supplements prevent fractures is weak and inconsistent: pooled analyses show modest reductions in total and vertebral fractures in some datasets, but effects attenuate or disappear in trials at lowest risk of bias, and benefits are not consistently observed for hip or forearm fractures; one notable exception is frail institutionalized elderly women with low baseline calcium/vitamin D status, where fracture reduction has been observed. For cardiovascular outcomes, trial-level meta-analyses and WHI subgroup reanalysis suggest calcium supplements (with or without vitamin D) may modestly increase cardiovascular event risk—particularly myocardial infarction—with the WHI overall signal potentially diluted by concurrent personal calcium use at baseline. Vitamin D co-supplementation does not appear to confer cardiovascular benefit in RCTs, and current evidence does not support vitamin D (with or without calcium) for cardiovascular prevention.

Key research gaps include better identification of subgroups in whom benefits outweigh harms (e.g., very low dietary calcium intake, frailty/institutionalization, baseline vitamin D deficiency, high baseline cardiovascular risk), and clarification of dose, formulation, and dosing pattern effects (e.g., bolus versus divided dosing; calcium citrate versus carbonate) on both skeletal and cardiovascular endpoints. More high-quality, adequately powered RCTs with fracture and cardiovascular events as prespecified primary outcomes—and with careful control of background calcium intake and personal supplement use—are needed to resolve residual uncertainty about net clinical benefit. Additional targeted studies are warranted in specific indications where calcium is used therapeutically (e.g., secondary hyperoxaluria) to define optimal dosing strategies and renal outcomes, and in premenstrual disorders to quantify efficacy and compare calcium against established first-line therapies.

Calcium and Its Effects on Health

Calcium Absorption and Supplements

Calcium absorption from supplements is similar to that from dietary sources, but dietary calcium has a greater effect on bone health. There is a contentious link between higher cardiovascular risks and calcium supplements compared to dietary calcium. Future research should focus on direct comparisons and long-term impacts of dietary versus supplemental calcium on bone density and cardiovascular risks.

Osteoporosis and Calcium Intake

Calcium, vitamin D, and vitamin K play significant roles in preventing and treating osteoporosis, a condition leading to weak, fracture-prone bones. Calcium supplements are beneficial for women post-menopause with low calcium intake, but have limited impact on women who are not deficient in vitamin D. Adequate calcium and vitamin D levels can reduce fracture rates in the elderly, especially those living in institutions.

Calcium in Biomaterials

Dense hydroxyapatite, similar in composition to human bone, is used in medical procedures such as bone grafts and shows promise for improving bone integration and medical treatments.

Calcium in Cellular Signaling

Mitochondria regulate calcium signaling within cells, playing a role in energy production and cell death. Calcium modulates mitochondrial metabolic activity and is involved in oxidative stress.

Calcium and Vitamin D for Health Outcomes

The Institute of Medicine Committee recognizes the importance of calcium and vitamin D for bone health, leading to updated dietary reference intakes. High levels of vitamin D do not necessarily provide additional benefits and can pose risks.

Rickets and Calcium Deficiency

Rickets, a disease caused by vitamin D or calcium deficiency, leads to weakened bones in children. Supplementation can heal rickets in cases of low dietary calcium.

Nutritional Rickets and Risk Factors

Nutritional rickets can result from inadequate vitamin D, calcium, or both, with risk factors including insufficient sunlight exposure, extended breastfeeding without supplementation, and poor weaning practices.

Calcium Supplementation and Bone Health

Calcium supplements can enhance calcium availability in the body without raising blood phosphate levels. Calcium supplementation in postmenopausal women contributes to bone health and is effective in preventing bone loss associated with calcium and estrogen deficiency.

Calcium Intake Recommendations

Excessive calcium intake may not be beneficial and could be harmful, leading to conditions such as hypercalciuria and kidney stones. Recommended daily allowances for calcium vary based on age and other factors, with supplementation advised for certain groups, especially post-menopausal women.

Dietary Calcium and Health

Identifying factors that reduce dietary calcium intake is crucial for improving public health. Strategies to improve calcium consumption should focus on educating the public about the benefits of dietary calcium and incorporating calcium-rich foods into diets.

Calcium Supplementation and Cardiovascular Risks

Calcium supplementation may modestly increase the risk of cardiovascular events, particularly myocardial infarction. It is suggested that the use of calcium supplements in managing osteoporosis should be reevaluated due to potential health risks.

References:

1. A Closer look at calcium absorption and the benefits and risks of dietary versus supplemental calcium
2. Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment
3. Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review
4. Interplay between mitochondria and cellular calcium signalling
5. The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know
6. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective
7. Nutritional rickets: deficiency of vitamin D, calcium, or both?
8. Rickets due to calcium deficiency
9. Rickets due to dietary calcium deficiency
10. Risk factors for nutritional rickets among children in Kuwait
11. Rickets in children of rural origin in South Africa: is low dietary calcium a factor?
12. Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, placebo-controlled cross-over human study
13. High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women
14. Calcium absorption from the ingestion of coral-derived calcium by humans
15. Applications of calcium and its supplement derived from marine organisms
16. Metal contents in Porites corals: Anthropogenic input of river run-off into a coral reef from an urbanized area, Okinawa
17. Effect of Praval bhasma (Coral calx), a natural source of rich calcium on bone mineralization in rats
18. Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss
19. Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis
20. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3
21. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB PATHWAY and kappaB elements
22. Mechanisms of intestinal calcium absorption
23. Molecular aspects of intestinal calcium absorption
24. An analysis of intestinal calcium transport across the rat intestine
25. Paracellular calcium transport across renal and intestinal epithelia
26. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
27. Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney
28. Alternative perspective on intestinal calcium absorption: proposed complementary actions of Ca(v)1.3 and TRPV6
29. Binding kinetics of calbindin-D(28k) determined by flash photolysis of caged Ca(2+)
30. Cytosolic Ca2+ buffers
31. Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes
32. Kinetic properties of Na+/Ca2+ exchange in basolateral plasma membranes of rat small intestine
33. Cellular and regional expression of transcripts of the plasma membrane calcium pump PMCA1 in rabbit intestine
34. Factors that influence absorption and secretion of calcium in the small intestine and colon
35. Solubility and intestinal transit time limit calcium absorption in rats
36. Dietary calcium and mineral/vitamin supplementation: a controversial problem
37. The importance of meeting calcium needs with foods
38. Racial differences in calcium retention in response to dietary salt in adolescent girls
39. Menopausal changes in calcium balance performance
40. Calcium absorption in women: relationships to calcium intake, estrogen status, and age
41. Factors associated with calcium absorption efficiency in pre- and perimenopausal women
42. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action
43. Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women
44. Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period
45. Calcium homeostasis during pregnancy and lactation in Brazilian women with low calcium intakes: a longitudinal study
46. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study
47. Intestinal calcium absorption of women during lactation and after weaning
48. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses
49. Calcium carbonate and reduction of levothyroxine efficacy
50. Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions
51. Requesting patterns for serum calcium concentration in patients on long-term lithium therapy
52. Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans
53. Mechanisms of the intestinal effects of dietary fats and milk products on colon carcinogenesis
54. Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences
55. Nutrients, platelet function and composition in nine groups of French and British farmers
56. Dietary calcium reduces blood pressure, parathyroid hormone, and platelet cytosolic calcium responses in spontaneously hypertensive rats
57. Modification of platelet and lymphocyte calcium handling and blood pressure by dietary sodium and calcium in genetically hypertensive rats
58. Improved glucose and lipid metabolism in genetically obese mice lacking aP2
59. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
60. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes
61. Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes
62. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis
63. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA)
64. Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men
65. Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study
66. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine
67. Estimation of total usual calcium and vitamin D intakes in the United States
68. Calcium and vitamin D disparities are related to gender, age, race, household income level, and weight classification but not vegetarian status in the United States: Analysis of the NHANES 2001-2008 data set
69. Epidemiology of fracture risk with advancing age
70. Epidemiology and outcomes of osteoporotic fractures
71. Combined resistance and balance-jumping exercise reduces older women's injurious falls and fractures: 5-year follow-up study
72. Calcium intake and risk of fracture: systematic review
73. Milk supplementation of the diet of postmenopausal Chinese women on a low calcium intake retards bone loss
74. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D-replete elderly patients
75. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation
76. Testosterone levels in athletes at rest and exhaustion: effects of calcium supplementation
77. Role of bile acids in colorectal carcinogenesis
78. Roles of endogenous substances and bacteria in colorectal cancer
79. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1
80. Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53
81. Characterization of the adsorption of conjugated and unconjugated bile acids to insoluble, amorphous calcium phosphate
82. Calcium phosphate formation in vitro. I. Factors affecting initial phase separation
83. Strategies to prevent and treat preeclampsia: evidence from randomized controlled trials
84. The relationship between calcium intake and pregnancy-induced hypertension: up-to-date evidence
85. [Hypocalciuria during pregnancy as a risk factor of preeclampsia]
86. Comparison of serum copper, zinc, calcium, and magnesium levels in preeclamptic and healthy pregnant women
87. Eclampsia and abnormal QTc
88. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
89. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
90. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group
91. Maternal calcium intake and offspring blood pressure
92. Maternal prenatal dietary potassium, calcium, magnesium, and infant blood pressure
93. A systematic review on the effects of maternal calcium supplementation on offspring's blood pressure
94. Gestational calcium supplementation and blood pressure in the offspring
95. Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial
96. Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomised controlled trial
97. Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children
98. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group
99. Calcium supplementation, bone mineral density and bone mineral content. Predictors of bone mass changes in adolescent mothers during the 6-month postpartum period
100. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium
101. Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects
102. Calcium and colon cancer: a review
103. Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects
104. Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium
105. Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro
106. Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa
108. Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats
109. High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin
110. Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat
111. Calcium solubility, intestinal sojourn time and paracellular permeability codetermine passive calcium absorption in rats
112. Calcium supplementation in clinical practice: a review of forms, doses, and indications
113. Calcium supplements: benefits and risks
114. Calcium supplementation and risk of dementia in women with cerebrovascular disease
115. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use
116. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden)
117. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort
118. A prospective study of calcium intake and incident and fatal prostate cancer
119. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer
120. Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials
121. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
122. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis
123. Adverse events from calcium supplementation: relationship to errors in myocardial infarction self-reporting in randomized controlled trials of calcium supplementation
124. A follow-up study on the effects of calcium-supplement withdrawal and puberty on bone acquisition of children
125. Calcium supplementation and bone mineral accretion in adolescent girls: an 18-mo randomized controlled trial with 2-y follow-up
126. A case report on over-replacement of oral calcium supplements causing acute pancreatitis
128. Calcium carbonate toxicity: the updated milk-alkali syndrome; report of 3 cases and review of the literature
129. Calcium supplements and arthritis
130. Severe hypercalcemia in a lactating woman in association with moderate calcium carbonate supplementation: a case report
131. Intestinal milk-bolus obstruction in formula-fed premature infants given high doses of calcium
132. Importance of dietary calcium and vitamin D in the treatment of hypercalcaemia in Williams-Beuren syndrome
133. Ingestion of antacid tablets (Rennie) and acute confusion
134. Pseudoxanthoma elasticum: high calcium intake in early life correlates with severity
135. Calcinosis cutis: part I. Diagnostic pathway.
     Nadine Reiter, Laila El-Shabrawi, Bernd Leinweber, Andrea Berghold, Elisabeth Aberer (2011) - Journal of the American Academy of Dermatology
136. Pathophysiology and Treatment of Enteric Hyperoxaluria.
     Celeste Witting, Craig B Langman, Dean Assimos, Michelle A Baum, Annamaria Kausz, Dawn Milliner, Greg Tasian, Elaine Worcester, Meaghan Allain, Melissa West, Felix Knauf, John C Lieske (2021) - Clinical journal of the American Society of Nephrology : CJASN
137. Acrylamide in Bakery Products: A Review on Health Risks, Legal Regulations and Strategies to Reduce Its Formation.
     Cristina Sarion, Georgiana Gabriela Codină, Adriana Dabija (2021) - International journal of environmental research and public health
138. The remineralisation of enamel: a review of the literature.
     Xiaoke Li, Jinfang Wang, Andrew Joiner, Jiang Chang (2014) - Journal of dentistry
139. Calcinosis Biomarkers in Adult and Juvenile Dermatomyositis.
     Melody P Chung, Carrie Richardson, David Kirakossian, Amir B Orandi, Lesley A Saketkoo, Lisa G Rider, Adam Schiffenbauer, Carlos A von Mühlen, Lorinda Chung (2020) - Autoimmunity reviews
140. The management of patients with enteric hyperoxaluria.
     John R Asplin (2016) - Urolithiasis
141. Calcium-fortified foods in public health programs: considerations for implementation.
     Cristina Palacios, Gabriela Cormick, G Justus Hofmeyr, Maria Nieves Garcia-Casal, Juan Pablo Peña-Rosas, Ana Pilar Betrán (2021) - Annals of the New York Academy of Sciences
142. Effect of nanolayering of calcium salts of phosphoric acid ester monomers on the durability of resin-dentin bonds.
     Fu-Cong Tian, Xiao-Yan Wang, Qi Huang, Li-Na Niu, Jan Mitchell, Zheng-Yi Zhang, Chandrani Prananik, Lu Zhang, Ji-Hua Chen, Lorenzo Breschi, David H Pashley, Franklin R Tay (2016) - Acta biomaterialia
143. Fetuin-A-containing calciprotein particles in mineral trafficking and vascular disease.
     Stephen G Holt, Edward R Smith (2016) - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
144. Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
     Xue-Xue Zhu, Xin-Yu Meng, Guo Chen, Jia-Bao Su, Xiao Fu, An-Jing Xu, Yao Liu, Xiao-Hui Hou, Hong-Bo Qiu, Qing-Yi Sun, Jin-Yi Hu, Zhuo-Lin Lv, Hai-Jian Sun, Hai-Bin Jiang, Zhi-Jun Han, Jian Zhu, Qing-Bo Lu (2024) - Cell communication and signaling : CCS
145. Metal ion chelation of poly(aspartic acid): From scale inhibition to therapeutic potentials.
     Hossein Adelnia, Fariba Sirous, Idriss Blakey, Hang Thu Ta (2023) - International journal of biological macromolecules
146. The Cell Origin and Role of Osteoclastogenesis and Osteoblastogenesis in Vascular Calcification.
     Wenhong Jiang, Zhanman Zhang, Yaodong Li, Chuanzhen Chen, Han Yang, Qiuning Lin, Ming Hu, Xiao Qin (2021) - Frontiers in cardiovascular medicine
147. Fibrillogenesis and Hydrogel Formation from Fibrinogen Induced by Calcium Salts.
     Dominik Hense, Oliver I Strube (2023) - Gels (Basel, Switzerland)
148. 3D Bio-Printability of Hybrid Pre-Crosslinked Hydrogels.
     Cartwright Nelson, Slesha Tuladhar, Loren Launen, Ahasan Habib (2021) - International journal of molecular sciences
149. Calcium citrate: from biochemistry and physiology to clinical applications.
     Andrea Palermo, Anda Mihaela Naciu, Gaia Tabacco, Silvia Manfrini, Pierpaolo Trimboli, Fabio Vescini, Alberto Falchetti (2019) - Reviews in endocrine & metabolic disorders
150. Systemic sclerosis skin is a primed microenvironment for soft tissue calcification-a hypothesis.
     Kyle A Burgess, Ariane L Herrick, Rachel E B Watson (2021) - Rheumatology (Oxford, England)
151. Hyperphosphataemia: treatment options.
     Fabio Malberti (2013) - Drugs
152. Effects of 10-MDP calcium salt on osteoblasts and fibroblasts.
     Lvhui Zhou, Yumin Wu, Zehua Bai, Jingjing Bian, Haifeng Xie, Chen Chen (2024) - Dental materials : official publication of the Academy of Dental Materials
153. The Impact of Fetal Programming in Ewe Nutrition with Chromium Propionate or Calcium Salts of Palm Oil on the Meat Quality and Bone of the Progeny.
     Luciano Brochine, Fernanda Ferreira Dos Santos, Flávia Mallaco Moreira, André Luis do Valle de Zoppa, Paulo Roberto Leme, Luis Orlindo Tedeschi, Sarita Bonagurio Gallo (2023) - Biological trace element research
154. Efficacy and mechanism of Shenqi Compound in inhibiting diabetic vascular calcification.
     Chan Yang, Ziyan Xie, Hanyu Liu, Xueru Wang, Zehua Zhang, Lian Du, Chunguang Xie (2023) - Molecular medicine (Cambridge, Mass.)
155. Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women : Postintervention Follow-up of a Randomized Clinical Trial.
     Cynthia A Thomson, Aaron K Aragaki, Ross L Prentice, Marcia L Stefanick, JoAnn E Manson, Jean Wactawski-Wende, Nelson B Watts, Linda Van Horn, James M Shikany, Thomas E Rohan, Dorothy S Lane, Robert A Wild, Rogelio Robles-Morales, Aladdin H Shadyab, Nazmus Saquib, Jane Cauley (2024) - Annals of internal medicine
156. Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents.
     Frederic Meyer, Joachim Enax, Matthias Epple, Bennett T Amaechi, Barbara Simader (2021) - Dentistry journal
157. Microbially Induced Calcium Carbonate Precipitation as a Bioremediation Technique for Mining Waste.
     Samantha M Wilcox, Catherine N Mulligan, Carmen Mihaela Neculita (2024) - Toxics
158. Exploring the Therapeutic Potential of 5-Fluorouracil-Loaded Calcium Carbonate Nanoparticles Combined with Natural Compound Thymoquinone for Colon Cancer Treatment.
     Xi Deng, Zhongming Yang, Kim Wei Chan, Md Zuki Abu Bakar (2024) - Pharmaceutics
159. Co-delivery of gemcitabine and Triapine by calcium carbonate nanoparticles against chemoresistant pancreatic cancer.
     Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Kai Ding, Mengjiao Zhou, Tianqing Liu (2023) - International journal of pharmaceutics
160. Calcium Supplementation to Prevent Preeclampsia: Translating Guidelines into Practice in Low-Income Countries.
     Moshood O Omotayo, Katherine L Dickin, Kimberly O O'Brien, Lynnette M Neufeld, Luz Maria De Regil, Rebecca J Stoltzfus (2016) - Advances in nutrition (Bethesda, Md.)
161. The Crystallization of Amorphous Calcium Carbonate is Kinetically Governed by Ion Impurities and Water.
     Marie Albéric, Luca Bertinetti, Zhaoyong Zou, Peter Fratzl, Wouter Habraken, Yael Politi (2018) - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
162. Recent Advances of Calcium Carbonate Nanoparticles for Biomedical Applications.
     Pengxuan Zhao, Yu Tian, Jia You, Xin Hu, Yani Liu (2022) - Bioengineering (Basel, Switzerland)
163. Stabilization and crystallization mechanism of amorphous calcium carbonate.
     Qihang Wang, Wenyang Huang, Jilin Wang, Fei Long, Zhengyi Fu, Jingjing Xie, Zhaoyong Zou (2025) - Journal of colloid and interface science
164. Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs.
     Xiaoting Zhou, Qihui Wang, Zipeng Lei, Ke Zhang, Shuxue Zhen, Huiqin Yao, Yan Zu (2024) - ACS omega
165. Biomimetic Use of Food-Waste Sources of Calcium Carbonate and Phosphate for Sustainable Materials-A Review.
     Sara Piras, Saniya Salathia, Alessandro Guzzini, Andrea Zovi, Stefan Jackson, Aleksei Smirnov, Cristiano Fragassa, Carlo Santulli (2024) - Materials (Basel, Switzerland)
166. Effect of Macro-, Micro- and Nano-Calcium Carbonate on Properties of Cementitious Composites-A Review.
     Mingli Cao, Xing Ming, Kaiyu He, Li Li, Shirley Shen (2019) - Materials (Basel, Switzerland)
167. Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer.
     Alexander S Timin, Alisa S Postovalova, Timofey E Karpov, Dmitrii Antuganov, Anastasia S Bukreeva, Darya R Akhmetova, Anna S Rogova, Albert R Muslimov, Svetlana A Rodimova, Daria S Kuznetsova, Mikhail V Zyuzin (2022) - Journal of controlled release : official journal of the Controlled Release Society
168. Biotic and abiotic effects on CO2 sequestration during microbially-induced calcium carbonate precipitation.
     Tugba Onal Okyay, Debora F Rodrigues (2015) - FEMS microbiology ecology
169. Size-dependent therapeutic efficiency of
     Darya R Akhmetova, Kseniya A Mitusova, Alisa S Postovalova, Arina S Ivkina, Albert R Muslimov, Mikhail V Zyuzin, Sergei A Shipilovskikh, Alexander S Timin (2024) - Biomaterials science
170. Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application.
     Han Liu, Zhiyang Wen, Zihan Liu, Yanfang Yang, Hongliang Wang, Xuejun Xia, Jun Ye, Yuling Liu (2024) - Acta pharmaceutica Sinica. B
171. Rationally designed calcium carbonate multifunctional trap for contaminants adsorption.
     Xin Sheng, Shengnan Chen, Zhiwei Zhao, Li Li, Yuanpeng Zou, Hui Shi, Penghui Shao, Liming Yang, Jingsheng Wu, Yaofu Tan, Xinyuan Lai, Xubiao Luo, Fuyi Cui (2023) - The Science of the total environment
172. Improvement of bio-cementation at low temperature based on Bacillus megaterium.
     Xiaohao Sun, Linchang Miao, Linyu Wu, Runfa Chen (2019) - Applied microbiology and biotechnology
173. The effect of phosphate binders, calcium and lanthanum carbonate on FGF23 levels in chronic kidney disease patients.
     Sagrario Soriano, Raquel Ojeda, Mencarnación Rodríguez, Yolanda Almadén, Mariano Rodríguez, Alejandro Martín-Malo, Pedro Aljama (2013) - Clinical nephrology
174. Calcium intake and bone mineral density: systematic review and meta-analysis.
     Vicky Tai, William Leung, Andrew Grey, Ian R Reid, Mark J Bolland (2015) - BMJ (Clinical research ed.)
175. Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review.
     Nathalie Demoulin, Selda Aydin, Valentine Gillion, Johann Morelle, Michel Jadoul (2022) - American journal of kidney diseases : the official journal of the National Kidney Foundation
176. Premenstrual Syndrome and Premenstrual Dysphoric Disorder.
     Sabrina Hofmeister, Seth Bodden (2016) - American family physician
177. Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar.
     Erin D Michos, Miguel Cainzos-Achirica, Amir S Heravi, Lawrence J Appel (2021) - Journal of the American College of Cardiology
178. Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes.
     Zixin Qiu, Qi Lu, Zhenzhen Wan, Tingting Geng, Rui Li, Kai Zhu, Lin Li, Xue Chen, An Pan, JoAnn E Manson, Gang Liu (2024) - Diabetes care
179. Calcium supplements and structure-activity relationship of peptide-calcium chelates: a review.
     Minghui Zhang, Kunlun Liu (2022) - Food science and biotechnology
180. The Formation, Structural Characteristics, Absorption Pathways and Bioavailability of Calcium-Peptide Chelates.
     Jiulong An, Yinxiao Zhang, Zhiwei Ying, He Li, Wanlu Liu, Junru Wang, Xinqi Liu (2022) - Foods (Basel, Switzerland)
181. Calcium and Cardiovascular Disease.
     Ian R Reid, Sarah M Birstow, Mark J Bolland (2017) - Endocrinology and metabolism (Seoul, Korea)
182. Dietary supplement use and colorectal cancer risk: a systematic review and meta-analyses of prospective cohort studies.
     Renate C Heine-Bröring, Renate M Winkels, Jacoba M S Renkema, Lea Kragt, Anne-Claire B van Orten-Luiten, Ettje F Tigchelaar, Doris S M Chan, Teresa Norat, Ellen Kampman (2015) - International journal of cancer
183. Calcium Supplementation- Efficacy and Safety.
     Ian R Reid (2025) - Current osteoporosis reports
184. Calcium and vitamin D metabolism in children in developing countries.
     John M Pettifor (2014) - Annals of nutrition & metabolism
185. Multi-modal molecular determinants of clinically relevant osteoporosis subtypes.
     Chunchun Yuan, Xiang-Tian Yu, Jing Wang, Bing Shu, Xiao-Yun Wang, Chen Huang, Xia Lv, Qian-Qian Peng, Wen-Hao Qi, Jing Zhang, Yan Zheng, Si-Jia Wang, Qian-Qian Liang, Qi Shi, Ting Li, He Huang, Zhen-Dong Mei, Hai-Tao Zhang, Hong-Bin Xu, Jiarui Cui, Hongyu Wang, Hong Zhang, Bin-Hao Shi, Pan Sun, Hui Zhang, Zhao-Long Ma, Yuan Feng, Luonan Chen, Tao Zeng, De-Zhi Tang, Yong-Jun Wang (2024) - Cell discovery
186. Oral calcium supplementation in peripartum dairy cows.
     Garrett R Oetzel (2013) - The Veterinary clinics of North America. Food animal practice
187. Calcium Intake and Iron Status in Human Studies: A Systematic Review and Dose-Response Meta-Analysis of Randomized Trials and Crossover Studies.
     Ajibola Ibraheem Abioye, Taofik A Okuneye, Abdul-Majeed O Odesanya, Olufunmilola Adisa, Asanat I Abioye, Ayorinde I Soipe, Kamal A Ismail, JaeWon F Yang, Luther-King Fasehun, Moshood O Omotayo (2021) - The Journal of nutrition
188. The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K.
     Grzegorz B Wasilewski, Marc G Vervloet, Leon J Schurgers (2019) - Frontiers in cardiovascular medicine

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