Brown Seaweed Extract Information

1) Conditions Studied

Brown seaweed extract has been studied for a variety of conditions, including:

• Obesity and weight loss
• Diabetes and blood sugar regulation
• Thyroid health
• Inflammation and immune system support
• Cardiovascular health

2) Effectiveness in Treating Conditions

Research findings on the effectiveness of brown seaweed extract for treating conditions have been mixed. Some studies suggest potential benefits in weight management and blood sugar control, but more rigorous and high-quality studies are needed to draw definitive conclusions.

3) Health Benefits

The health benefits attributed to brown seaweed extract include:

• Antioxidant properties that may protect against cellular damage
• Potential anti-inflammatory effects
• Support for cardiovascular health by helping to reduce cholesterol levels
• May aid in digestion and promote gut health
• Possibly supporting thyroid function due to its natural iodine content

4) Downsides

While brown seaweed extract is generally considered safe for most people, there are some potential downsides, including:

• Excessive iodine intake, which can disrupt thyroid function
• Possible allergic reactions in sensitive individuals
• Interactions with certain medications, particularly blood thinners
• Presence of heavy metals or contaminants depending on the source of the seaweed

5) Genetic Variations and Effects

Currently, there is limited research on the interaction between brown seaweed extract and specific genetic variations. Some individuals with genetic predispositions to thyroid disorders may need to exercise caution due to the iodine content in the extract. Personalized nutrition and medicine are emerging fields, and future research may provide more insights into these interactions.

Summary of Research on Brown Seaweed Extract and Fucoxanthin

Introduction

Fucoxanthin, a marine carotenoid derived from brown seaweed, has been extensively researched for its potential health benefits and biological activities. It is found in various marine organisms and plays a role in the food chain and metabolic pathways. The following summary provides insights into the properties and applications of fucoxanthin.

Antioxidant Properties

Fucoxanthin exhibits strong antioxidant properties, effectively scavenging radicals and protecting against oxidative damage. This may contribute to its therapeutic potential in treating or preventing diseases associated with oxidative stress.

Anti-inflammatory and Anti-cancer Effects

Studies have demonstrated the anti-inflammatory and anti-cancer effects of fucoxanthin, including its ability to inhibit the growth of various cancer cells and reduce inflammation by downregulating pro-inflammatory pathways.

Metabolic and Anti-obesity Activities

Fucoxanthin has shown promise in managing obesity by modulating lipid metabolism, reducing white adipose tissue, and potentially enhancing energy expenditure through the activation of uncoupling proteins. It has also been associated with improved blood glucose levels and reduced insulin resistance.

Potential Therapeutic Applications

The diverse biological activities of fucoxanthin suggest its potential as a natural therapeutic agent for treating various inflammatory conditions, obesity, diabetes, and certain types of cancer. Research indicates that fucoxanthin could be used as a functional food ingredient or in combination with other treatments to enhance efficacy.

Conclusion

Fucoxanthin from brown seaweed extract shows significant promise in pharmacological research due to its antioxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. Further studies are needed to fully understand its mechanisms and optimize its use in health and nutrition.

References:

1. Carotenoids in marine animals
2. Allenic and cumulenic lipids
3. Light-Harvesting Function in the Diatom Phaeodactylum tricornutum: I. Isolation and Characterization of Pigment-Protein Complexes
4. Comparison of oligomeric states and polypeptide compositions of fucoxanthin chlorophyll a/c-binding protein complexes among various diatom species
5. Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom Odontella aurita
6. Compounds associated with algal surfaces mediate epiphytic colonization of the marine macroalga Fucus vesiculosus
7. Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity
8. Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages
9. Isolation and Partial Characterization of Bioactive Fucoxanthin from Himanthalia elongata Brown Seaweed: A TLC-Based Approach
10. Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase
11. Supercritical carbon dioxide extraction of fucoxanthin from Undaria pinnatifida
12. Fucoxantin: a treasure from the sea
13. Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads
14. A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum
15. Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization
16. Fucoxanthin metabolites in egg yolks of laying hens
17. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice
18. Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro
19. Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin
20. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin
21. Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)
22. Fucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na(+)K(+)-ATPase [corrected] and antioxidant enzyme activities in rats
23. Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract
24. The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
25. Esterification of xanthophylls by human intestinal Caco-2 cells
26. Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats
27. Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice
28. Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites
29. Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D
30. Low bioavailability of dietary epoxyxanthophylls in humans
31. Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice
32. Keto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissues
33. Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite
34. Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells
35. Cytochrome P-450 3A4: regulation and role in drug metabolism
36. Microglial physiology: unique stimuli, specialized responses
37. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
38. Microglial activation and chronic neurodegeneration
39. Fucoxanthin ameliorates inflammation and oxidative reponses in microglia
40. The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet
41. Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats
42. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
43. Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model
44. Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice
45. Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice
46. Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice
47. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice
48. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
49. Thermogenic mechanisms in brown fat
50. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient
51. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases
52. Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice
53. Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice
54. Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression
55. Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways
56. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells
57. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
58. Insulin resistance associated to obesity: the link TNF-alpha
59. Extracts of marine algae show inhibitory activity against osteoclast differentiation
60. Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells
61. Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites
62. Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH)
63. Scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system
64. Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems
65. Strategies of antioxidant defense
66. Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage
67. Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity
68. NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction
69. Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway
70. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo
71. Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages
72. Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
73. Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage
74. A marine carotenoid, fucoxanthin, induces regulatory T cells and inhibits Th17 cell differentiation in vitro
75. Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells
76. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
77. Using chemopreventive agents to enhance the efficacy of cancer therapy
78. Involvement of nuclear transcription factor-kappa B in low-dose doxorubicin-induced drug resistance of cervical carcinoma cells
79. Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells
80. In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)

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