Bhringaraj - NutraPedia

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Bhringaraj (Eclipta prostrata)

1) Conditions Studied for Bhringaraj

Bhringaraj has been studied in the context of several health conditions. Traditionally, it has been used for:

  • Hair growth and preventing hair loss
  • Liver disorders like hepatitis and jaundice
  • Skin diseases
  • Respiratory issues
  • Memory enhancement
  • Gastrointestinal ailments
  • Age-related vision loss

2) Efficacy in Treating Conditions

While traditional usage suggests potential benefits, scientific evidence on Bhringaraj's efficacy is limited and mixed. Some studies have found that it may promote hair growth and improve liver function, but further research is needed to conclusively determine its effectiveness for various conditions.

3) General Health Benefits

Bhringaraj is believed to offer a range of health benefits, including:

  • Antioxidant properties
  • Anti-inflammatory effects
  • Improving hair and scalp health
  • Supporting liver function
  • Strengthening the immune system

4) Potential Downsides

While Bhringaraj is generally considered safe, there are potential downsides, including:

  • Allergic reactions in sensitive individuals
  • Gastrointestinal discomfort
  • Potential interaction with other medications
  • Insufficient evidence on long-term safety

Pregnant or breastfeeding women should avoid using Bhringaraj due to a lack of safety data.

5) Genetic Variations and Bhringaraj

There is currently no substantial evidence to suggest that Bhringaraj is particularly beneficial or harmful for specific genetic variations. The impact of genetic differences on the response to Bhringaraj has not been thoroughly studied and would require more detailed scientific research.

Summary of Research on Bhringaraj (Eclipta alba)

Anti-Hepatitis C Virus Properties: A study highlighted the anti-HCV properties of Eclipta alba, traditionally used for liver ailments. The plant extract was found to inhibit HCV replicase activity and virus replication in cell cultures. Phytochemicals wedelolactone, luteolin, and apigenin were identified as key inhibitory compounds, demonstrating potential for alternative HCV treatments.

Genetic Modification for Enhanced Metabolite Production: Eclipta alba was genetically modified using Agrobacterium rhizogenes LBA 9402 to increase secondary metabolite production. These metabolites showed potential against phospholipase A(2) and snake venom myotoxicity. Clone 19 exhibited the highest concentration of beneficial compounds.

Liver-Protective Effects: The study identified coumestans from Eclipta alba as active compounds responsible for its hepatoprotective effects, which may have implications for therapeutic applications.

Effect on Maternal Aggression: Eclipta alba extract was found to significantly reduce aggressive behavior in mother rats, suggesting potential to mitigate maternal aggression.

Treatment for Amlapitta: Bhringaraj tablets showed marked improvement in patients with Amlapitta, supporting its effectiveness as a treatment for the condition.

Mosquito Larvicidal and Ovicidal Properties: Eclipta alba extracts demonstrated promising larvicidal and ovicidal activities against Aedes aegypti, the vector for chikungunya and dengue fever.

Effects on Hair Growth: Studies on Eclipta alba extracts showed positive effects on hair growth promotion in animal models, with potential implications for treating alopecia.

Neuropharmacological Activities: Eclipta alba exhibited nootropic activity and stress attenuation in rats, indicating potential for cognitive enhancement and stress-related disorder treatments.

Antioxidant Properties: A combined extract of Eclipta alba and Piper longum displayed superior antioxidant properties compared to their individual extracts.

Hepatotoxicity Concerns: A case report suggested potential liver toxicity associated with the use of Indian Ayurvedic herbal products containing Eclipta alba.

References:


  1. Identification and evaluation of anti hepatitis C virus phytochemicals from Eclipta alba
  2. Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans
  3. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea
  4. Impact of the aqueous extract of Eclipta alba on maternal aggression in rats
  5. Fundamental approach in the management of Drava Bahula Amlapitta with Bhringaraja (Eclipta alba)
  6. Mosquito larvicidal and ovicidal properties of Eclipta alba (L.) Hassk (Asteraceae) against chikungunya vector, Aedes aegypti (Linn.) (Diptera: Culicidae)
  7. Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae)
  8. Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)
  9. Hair growth promoting activity of Eclipta alba in male albino rats
  10. Phenolics and other constituents from Eclipta alba
  11. DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1
  12. DNA damaging steroidal alkaloids from eclipta alba from the suriname rain forest
  13. Eclalbatin, a triterpene saponin from Eclipta alba
  14. Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells
  15. Bio-assay guided isolation of alpha-glucosidase inhibitory constituents from Eclipta alba
  16. [Isolation and identification of ecliptasaponin D from Eclipta alba (L.) Hassk]
  17. [Chemical constituents of Eclipta alba (L.) Hassk]
  18. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone
  19. Investigation on the effect of eclipta alba on animal models of learning and memory
  20. Neuropharmacological profile of Eclipta alba (Linn.) Hassk
  21. Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats
  22. Evaluation of antiaggressive activity of Eclipta alba in experimental animals
  23. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk
  24. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study
  25. Experimental evaluation of the analgesic property of eclipta alba (L) hassk
  26. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study
  27. Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase
  28. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats
  29. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica
  30. Evaluation of Anti -Inflammatory Activity of Eclipta alba in rats
  31. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves
  32. The protective effect of Eclipta alba on carbon tetrachloride-induced acute liver damage
  33. Hepatoprotective effects of Eclipta alba on subcellular levels in rats
  34. A new receipt for liver injury
  35. Antihepatotoxic activity of eclipta alba, tephrosia purpurea and boerhaavia diffusa
  36. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study
  37. Eclipta alba extract with potential for hair growth promoting activity
  38. Development and evaluation of polyherbal formulation for hair growth-promoting activity
  39. Antioxidant activity of combined ethanolic extract of Eclipta alba and Piper longum Linn
  40. Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment


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