7 Keto Dhea - NutraPedia

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7 Keto DHEA Overview

1) Conditions Studied

7 Keto DHEA has been studied for a range of conditions including, but not limited to:

  • Obesity and weight loss
  • Aging
  • Metabolic syndrome
  • Improving immune function
  • Increase in metabolism
  • Memory enhancement

2) Efficacy in Treating Conditions

The effectiveness of 7 Keto DHEA in treating these conditions varies. Some studies suggest that it may help with weight loss by increasing metabolism without the side effects associated with its parent compound DHEA. However, evidence is limited and more research is needed to conclusively determine its efficacy for most conditions.

3) Health Benefits

Reported health benefits of 7 Keto DHEA include:

  • Enhanced weight loss when combined with diet and exercise
  • Possible immune system enhancement
  • May improve lean body mass
  • Potentially increased metabolic rate
  • Anti-aging effects

4) Downsides

While 7 Keto DHEA is generally considered safe, it may have some downsides:

  • Limited long-term safety data
  • Potential for hormone-related side effects
  • Interactions with certain medications
  • Not recommended for pregnant or breastfeeding women
  • May not be as effective for all individuals

5) Genetic Variations

There is currently limited research on the interaction between 7 Keto DHEA and specific genetic variations. As with many supplements, individual responses can vary due to genetic differences, but more studies are needed to provide definitive conclusions on beneficial or harmful effects related to particular genetic profiles.

Research Summary on 7 Keto DHEA

Effects on Thyroid Function

A study involving 21 men over 8 days found that transdermal application of 25 mg 7-oxo-DHEA temporarily influenced thyroid parameters, increasing thyroid-stimulating hormone (TSH) and thyroid hormones (free thyroxine and triiodothyronine) during treatment. However, these levels returned to baseline post-treatment, indicating a temporary effect.

Development of 7-oxo-DHEA Radioimmunoassay

A newly developed RIA method for measuring 7-oxo-DHEA in human serum showed precision and accuracy, with low cross-reactivity to related steroids. It was applied to 215 individuals, revealing no notable sex differences in 7-oxo-DHEA levels, except in boys under 10 years old.

Safety and Pharmacokinetics of 3-acetyl-7-oxo-DHEA

A study on healthy male volunteers showed that 3-acetyl-7-oxo-DHEA is safe and well-tolerated, with dose-dependent levels of its metabolic product, 7-oxo-DHEA-S, which did not accumulate over time.

HPLC Method for 7-oxo-DHEA-3beta-sulfate Measurement

An HPLC method for measuring 7-oxo-DHEA-3beta-sulfate in human plasma was developed, proving to be simple, reproducible, and reliable for quantitative determination.

Impact on Metabolism and Immune Response

Various studies indicated that 7-oxo-DHEA and its derivatives may influence liver enzyme induction, glucocorticoid metabolism, and immune response, with potential therapeutic uses in autoimmune and inflammatory diseases.

Thermogenic Enzyme Induction

Research on DHEA derivatives found that activity is increased in steroids hydroxylated at the 7 alpha or 7 beta position and transformed into a 7-oxo derivative, suggesting these derivatives could induce thermogenic enzymes.

Memory Retention and PTSD Treatment

7-oxo-DHEA showed potential benefits for memory retention in mice and might be a promising treatment for PTSD in women, as indicated by case reports on its use for treatment-resistant PTSD.

Anti-obesity Medication

A study comparing obese and lean adolescents found that 7-oxygenated DHEA derivatives might have a gender-specific role in obesity, particularly in boys.

Resting Metabolic Rate in Obese Individuals

Studies showed that 7-oxo-DHEA and a mixture containing it, HUM5007, could reverse the decrease in resting metabolic rate associated with dieting, which may aid in weight management for obese individuals.

Glucocorticoid Metabolism

7-oxo-DHEA derivatives were shown to interact with the enzyme 11beta-HSD1, affecting the metabolism of glucocorticoids and potentially modulating cortisol levels in the body.

References:


  1. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function
  2. A novel radioimmunoassay of 7-oxo-DHEA and its physiological levels
  3. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers
  4. Development and validation of a high-performance liquid chromatography assay for the quantitative determination of 7-oxo-dehydroepiandrosterone-3beta-sulfate in human plasma
  5. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone
  6. Bovine liver slices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA)
  7. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
  8. Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions
  9. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes
  10. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes
  11. Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology
  12. Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports
  13. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice
  14. Non-specific steroidal esterase activity and distribution in human and other mammalian tissues
  15. Interactions between dehydroepiandrosterone and glucocorticoid metabolism in pig kidney: nuclear and microsomal 11beta-hydroxysteroid dehydrogenases
  16. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
  17. Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids
  18. Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers
  19. The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice
  20. Dehydroepiandrosterone and its sulfate enhance memory retention in mice
  21. Dehydroepiandrosterone sulfate improves memory in aging mice
  22. 7-hydroxylated derivatives of dehydroepiandrosterone as possibly related to menstrual mood change in healthy women
  23. A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule
  24. Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital
  25. 3-acetyl-7-oxo-dehydroepiandrosterone for healing treatment-resistant posttraumatic stress disorder in women: 5 case reports
  26. 7-oxygenated derivatives of dehydroepiandrosterone and obesity
  27. Concerning the mechanism of increased thermogenesis in rats treated with dehydroepiandrosterone
  28. Induction of thermogenic enzymes by DHEA and its metabolites
  29. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis
  30. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults
  31. Effect of lean system 7 on metabolic rate and body composition
  32. Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH
  33. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
  34. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1
  35. Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1
  36. 7alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1
  37. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?
  38. Dehydroepiandrosterone and its 7-hydroxylated metabolites do not interfere with the transactivation and cellular trafficking of the glucocorticoid receptor
  39. Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity
  40. DHEA metabolites activate estrogen receptors alpha and beta
  41. Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells
  42. Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression
  43. Evolving utility of sex hormone-binding globulin measurements in clinical medicine


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